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Titolo:
The relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow and hypoxia in an animal stroke model
Autore:
Lythgoe, MF; Williams, SR; Busza, AL; Wiebe, L; McEwan, AJB; Gadian, DG; Gordon, I;
Indirizzi:
Univ Coll London, RCS, Biophys Unit, Inst Child Hlth,Sch Med, London WC1N 1EH, England Univ Coll London London England WC1N 1EH h Med, London WC1N 1EH, England Great Ormond St Hosp Children NHS Trust, Dept Radiol, London WC1N 3JH, England Great Ormond St Hosp Children NHS Trust London England WC1N 3JH England Univ Alberta, Edmonton, AB, Canada Univ Alberta Edmonton AB CanadaUniv Alberta, Edmonton, AB, Canada
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 41, anno: 1999,
pagine: 706 - 714
SICI:
0740-3194(199904)41:4<706:TRBMRD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY OCCLUSION; WATER DIFFUSION; ENERGY-METABOLISM; ISCHEMIC-INJURY; FOCAL ISCHEMIA; WEIGHTED MRI; BRAIN; SPECTROSCOPY; RAT; INFARCTION;
Keywords:
Tc-99m-HMPAO; cerebral ischaemia; I-125-IAZA; diffusion-weighted NMR imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Lythgoe, MF Univ Coll London, RCS, Biophys Unit, Inst Child Hlth,Sch Med, 30 GuildfordSt, London WC1N 1EH, England Univ Coll London 30 Guildford St London England WC1N 1EH land
Citazione:
M.F. Lythgoe et al., "The relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow and hypoxia in an animal stroke model", MAGN RES M, 41(4), 1999, pp. 706-714

Abstract

This study examined the relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow (Tc-99m-hexamethylpropylene amine oxime) and cerebral hypoxia (I-125-iodoazomycin arabinoside) in a rat model of stroke. Middle cerebral artery occlusion in the rat was performed using an intraluminal suture approach. Diffusion, hypoxia, and blood flow maps were acquired 2 hr following occlusion, and were comparedwith T2 images and histology at 7 hr, Two hours following middle cerebral artery occlusion the lesion distributions from the diffusion maps and hypoxic autoradiographs were similar. The blood flow threshold for increased uptake of the hypoxic marker was approximately 34 +/- 7% of the normal flow. The combination of diffusion or hypoxic images with perfusion maps allowed differentiation between four regions: 1) normal tissue; 2) a region of decreased perfusion but normal diffusion and normal uptake of hypoxic marker; 3)a region of decreased perfusion, decreased diffusion and increased uptake of hypoxic marker; 4) a region of decreased perfusion, decreased diffusion and low uptake of hypoxic marker. The areas for increased uptake of hypoxicmarker and decreased diffusion are equivalent, indicating similar blood flow thresholds. Regions of oligaemic misery perfusion, ischaemic misery perfusion and lesion core may be delineated with the combination of diffusion or hypoxic images and perfusion maps. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:08:59