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Titolo:
Concentrations of human cardiac phosphorus metabolites determined by SLOOPP-31 NMR spectroscopy
Autore:
Meininger, M; Landschutz, W; Beer, M; Seyfarth, T; Horn, V; Pabst, T; Haase, A; Hahn, D; Neubauer, S; von Kienlin, M;
Indirizzi:
Univ Wurzburg, Med Klin, Wurzburg, Germany Univ Wurzburg Wurzburg Germany iv Wurzburg, Med Klin, Wurzburg, Germany Univ Wurzburg, Inst Rontgendiagnost, Wurzburg, Germany Univ Wurzburg Wurzburg Germany Inst Rontgendiagnost, Wurzburg, Germany Univ Wurzburg, Inst Phys, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 nst Phys, D-8700 Wurzburg, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 41, anno: 1999,
pagine: 657 - 663
SICI:
0740-3194(199904)41:4<657:COHCPM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; CORONARY-ARTERY DISEASE; HUMAN HEART; HYPERTROPHIC CARDIOMYOPATHY; MR SPECTROSCOPY; QUANTIFICATION; LOCALIZATION; SATURATION; SPECTRA;
Keywords:
heart; human; absolute quantitation; P-31 NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: von Kienlin, M Hoffman La Roche, PRPC S, G5-512, CH-4070 Basel, Switzerland Hoffman La Roche G5-512 Basel Switzerland CH-4070 tzerland
Citazione:
M. Meininger et al., "Concentrations of human cardiac phosphorus metabolites determined by SLOOPP-31 NMR spectroscopy", MAGN RES M, 41(4), 1999, pp. 657-663

Abstract

Human cardiac P-31 nuclear magnetic resonance (NMR) spectra are usually quantified in relative terms, i.e., the ratio of metabolite signals is calculated. If P-31 NMR spectroscopy of the heart is to emerge as a clinically relevant diagnostic modality, reliable quantification of absolute concentrations of P-31 metabolites is required. We applied spectral localization with optimal point spread function (SLOOP) P-31 NMR spectroscopy to measure absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in human myocardium. The accuracy of the quantification was first validated in a phantom study. Seven healthy volunteers (aged 19-29 years) were then examined at 1.5 T using a nominal spatial resolution of 25 mL. SLOOP allowed us to obtain localized spectra from compartments anatomically matched to the left ventricular wall. The a priori knowledge of the anatomical structure was obtained from H-1 images. The spatially varying effects of saturation, off-resonance, and sensitivity were considered during the reconstruction process. Metabolites were quantified with reference to an external P-31standard. Concentrations of 9.0 +/- 1.2 and 5.3 +/- 1.2 mmol/kg wet wt (mean +/- SD, n = 9) were determined for PCr and ATP in normal heart, respectively. The influence of nuclear Overhauser enhancement on metabolite quantification is discussed. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:12:14