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Titolo:
Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study
Autore:
Becerra, LR; Breiter, HC; Stojanovic, M; Fishman, S; Edwards, A; Comite, AR; Gonzalez, RG; Borsook, D;
Indirizzi:
Massachusetts Gen Hosp, Pain Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Pain Ctr, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Nucl Magnet Resounance Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ance Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 rit Care, Boston, MA 02114 USA Massachusetts Gen Hosp, Neural Plast Res Grp, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Res Grp, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Neuroradiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 roradiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 41, anno: 1999,
pagine: 1044 - 1057
SICI:
0740-3194(199905)41:5<1044:HBAUCT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; HUMAN CINGULATE CORTEX; FUNCTIONAL NEUROANATOMY; PERIAQUEDUCTAL GRAY; NEUROPATHIC PAIN; HYPOTHALAMUS; RESPONSES; SKIN; NUCLEUS; MONKEY;
Keywords:
fMRI; pain; heat; Peltier thermode;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Borsook, D Massachusetts Gen Hosp, Pain Ctr, ACC-324,Fruit St, Boston, MA 02114 USA Massachusetts Gen Hosp ACC-324,Fruit St Boston MA USA 02114 USA
Citazione:
L.R. Becerra et al., "Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study", MAGN RES M, 41(5), 1999, pp. 1044-1057

Abstract

Brain activity was studied with functional magnetic resonance imaging (fMRI) following thermal stimulation, Two groups (n = 6/ group) of human male volunteers were given up to four noxious (46 degrees C) and four non-noxious(41 degrees C) stimuli. In the 46 degrees C experiment, positive signal changes were found in the frontal gyri, anterior and posterior cingulate gyrus, thalamus, motor cortex, somatosensory cortex (SI and SII), supplementarymotor area, insula, and cerebellum. Low-level negative signal changes appeared in the amygdala and hypothalamus. Ail regions activated by 46 degrees C were also activated by 41 degrees C, However, except for SI and thalamus,significantly more activation was observed for the 46 degrees C stimulus, A significant attenuation of the signal change was observed by the third stimulus for the 46 degrees C, but not for 41 degrees C experiment. Similar findings were replicated in the second group. These fMRI findings specify differences between somatosensory and pain sensation and suggest a number of rich avenues for future research. Magn Reson Med 41:1044-1057, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 28/09/20 alle ore 15:29:32