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Titolo:
Fatty acids, antioxidants, and coronary heart disease from an epidemiological perspective
Autore:
Kromhout, D;
Indirizzi:
Natl Inst Publ Hlth & Environm, Div Publ Hlth Res, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands
Titolo Testata:
LIPIDS
, volume: 34, anno: 1999, supplemento:, S
pagine: S27 - S31
SICI:
0024-4201(1999)34:<S27:FAAACH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; VITAMIN-E CONSUMPTION; MYOCARDIAL-INFARCTION; BETA-CAROTENE; 7 COUNTRIES; CARDIOVASCULAR-DISEASE; FLAVONOID INTAKE; ADIPOSE-TISSUE; RISK; MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kromhout, D Natl Inst Publ Hlth & Environm, Div Publ Hlth Res, POB 1, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm POB 1 Bilthoven Netherlands NL-3720 BA
Citazione:
D. Kromhout, "Fatty acids, antioxidants, and coronary heart disease from an epidemiological perspective", LIPIDS, 34, 1999, pp. S27-S31

Abstract

Oxidized low density lipoproteins (LDL) play a major role in the development of atherosclerosis. Saturated fatty acids, especially fatty acids with 12-16 carbon atoms, are the most important determinants of the LDL cholesterol level. The LDL lipoprotein fraction can be oxidized by, e.g., smoking. Oxidative damage of LDL lipoproteins can be prevented by nutritive, e.g., vitamin E, and nonnutritive antioxidants, e.g., flavonoids. It can therefore be hypothesized that fatty acids and antioxidants are important determinants of coronary heart disease (CHD). There is a large body of evidence from prospective studies that LDL cholesterol-lowering is associated with a lowerCHD risk. The evidence for a protective effect of antioxidants on CHD riskis much weaker and is most promising for vitamin E and flavonoids. The Seven Countries Study showed that at the population level saturated fat, cigarette smoking, and flavonoids are important determinants of long-term CHD mortality. These results suggest that a diet low in saturated fat and rich inantioxidants in combination with no smoking is associated with low CHD risk.

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Documento generato il 05/04/20 alle ore 09:48:35