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Titolo:
Changes in local hepatic blood perfusion during interstitial laser-inducedthermotherapy of normal rat liver measured by interstitial laser Doppler flowmetry
Autore:
Sturesson, C; Ivarsson, K; Andersson-Engels, S; Tranberg, KG;
Indirizzi:
Lund Inst Technol, Dept Phys, S-22100 Lund, Sweden Lund Inst Technol Lund Sweden S-22100 l, Dept Phys, S-22100 Lund, Sweden Univ Lund, Dept Surg, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Dept Surg, Lund, Sweden
Titolo Testata:
LASERS IN MEDICAL SCIENCE
fascicolo: 2, volume: 14, anno: 1999,
pagine: 143 - 149
SICI:
0268-8921(1999)14:2<143:CILHBP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE CONTROL; INFLOW OCCLUSION; HYPERTHERMIA; FLOW; TUMORS; MICROCIRCULATION; THERAPY; CANCER;
Keywords:
interstitial laser therapy; liver; perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Sturesson, C Lund Inst Technol, Dept Phys, POB 118, S-22100 Lund, Sweden Lund Inst Technol POB 118 Lund Sweden S-22100 0 Lund, Sweden
Citazione:
C. Sturesson et al., "Changes in local hepatic blood perfusion during interstitial laser-inducedthermotherapy of normal rat liver measured by interstitial laser Doppler flowmetry", LASER MED S, 14(2), 1999, pp. 143-149

Abstract

Interstitial laser Doppler flowmetry was used to measure the effect of interstitial laser-induced thermotherapy on local blood perfusion in normal rat liver in the peripheral treatment region elevated to hyperthermic temperatures. The Nd:YAG laser emitting at 1064 nm was utilised as heat generationsource. The plane-cut tip of an optical fibre was placed in the middle of the exteriorised left liver lobe. Blood perfusion and temperature were measured in the liver parenchyma 4 mm from the laser fibre. The temperature at the location of the liver temperature sensor was maintained at 41 or 44 degrees C during 30 min by regulating the power of the heating laser. The laser Doppler signal was recorded during and after heat treatment, for a total time of 60 min. At 41 degrees C, a significant increase in perfusion up to 1.3 times the initial value was observed 2-16 min after start of treatment. At 44 degrees C, perfusion decreased continuously during and after treatment, and was significantly different from control 40 min after start of treatment. The results may be valuable in assessing the thermal response of tissues surrounding the target in interstitial laser-induced thermotherapy of liver tumours during conditions of normal blood flow.

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Documento generato il 09/08/20 alle ore 23:00:40