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Titolo:
Increased blood glucose and insulin, body size, and incident colorectal cancer
Autore:
Schoen, RE; Tangen, CM; Kuller, LH; Burke, GL; Cushman, M; Tracy, RP; Dobs, A; Savage, PJ;
Indirizzi:
Univ Pittsburgh, Dept Med & Epidemiol, Pittsburgh, PA USA Univ PittsburghPittsburgh PA USA pt Med & Epidemiol, Pittsburgh, PA USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Wake Forest Univ, Sch Med, Dept Publ Hlth & Sci, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Univ Vermont, Dept Med, Burlington, VT USA Univ Vermont Burlington VT USA niv Vermont, Dept Med, Burlington, VT USA Univ Vermont, Dept Pathol, Burlington, VT USA Univ Vermont Burlington VT USA Vermont, Dept Pathol, Burlington, VT USA Univ Vermont, Dept Biochem, Burlington, VT USA Univ Vermont Burlington VTUSA Vermont, Dept Biochem, Burlington, VT USA Johns Hopkins Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ns Univ, Dept Med, Baltimore, MD USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 13, volume: 91, anno: 1999,
pagine: 1147 - 1154
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISCERAL ADIPOSE-TISSUE; COLON-CANCER; DIABETES-MELLITUS; FAT DISTRIBUTION; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; RISK-FACTORS; COMPUTED-TOMOGRAPHY; BINDING-PROTEIN; PREMENOPAUSAL WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Schoen, RE PUH, Div Gastroenterol & Hepatol, Mezzanine Level,C Wing,200 Lothrop St, Pittsburgh, PA 15213 USA PUH Mezzanine Level,C Wing,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
R.E. Schoen et al., "Increased blood glucose and insulin, body size, and incident colorectal cancer", J NAT CANC, 91(13), 1999, pp. 1147-1154

Abstract

Background: Abdominal obesity-an elevated level of visceral adipose tissue-has been linked to colorectal cancer. Furthermore, elevated levels of visceral adipose tissue have been associated with hyperinsulinemia, and insulinis a growth factor in the colon. We assessed whether waist circumference, a surrogate measure of visceral adipose tissue, and metabolic parameters associated with visceral adipose tissue were related to colorectal cancer, Methods: In the Cardiovascular Health Study cohort, we examined the relationship of baseline measurements of body size, glucose, insulin, and lipoproteins to incident colorectal cancer. All P values are two-sided. Results: Among 5849 participants, 102 incident cases of colorectal cancer were identified. Individuals in the highest quartile of fasting glucose had a nearly twofold increased risk of colorectal cancer (relative risk [RR] = 1.8; 95% confidence interval [CI] = 1.0-3.1), and the linear trend RR (LT RR = 1.2; 95% CI = 1.0-1.5) for fasting glucose level was statistically significant (P =.02), Glucose and insulin levels 2 hours after oral glucose challenge also exhibited statistically significant associations with colorectal cancer (2-hour glucose levels: RR = 2.4 [95% CI = 1.2-4.7]/LT RR = 1.3 [95% CI = 1.0-1.6; P =.02]; 2-hour insulin levels: RR = 2.0 [95% CI = 1.0-3.8]/LT RR = 1.2[95% CI = 1.0-1.5; P =.04]), Analysis of fasting insulin levels suggested a threshold effect, with values above the median associated with colorectalcancer (RR = 1.6; 95% CI = 1.1-2.4; P =.02). Higher levels of waist circumference were also statistically significantly associated with colorectal cancer (RR = 1.9; 95% CI = 1.1-3.3; P =.02). Conclusions: These data provide,to our knowledge, the first direct evidence of an association between elevated visceral adipose tissue level, its associated metabolic effects, and colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 17:03:07