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Titolo:
Inherited susceptibility to bleomycin-induced chromatid breaks in culturedperipheral blood lymphocytes
Autore:
Cloos, J; Nieuwenhuis, EJC; Boomsma, DI; Kuik, DJ; van der Sterre, MLT; Arwert, F; Snow, GB; Braakhuis, BJM;
Indirizzi:
Vrije Univ Amsterdam, Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands Vrije UnivAmsterdam Amsterdam Netherlands chol, Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Epidemiol & Biostat, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands stat, Amsterdam, Netherlands Vrije Univ Amsterdam, Dept Human Genet, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands enet, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 13, volume: 91, anno: 1999,
pagine: 1125 - 1130
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AERODIGESTIVE TRACT; SQUAMOUS-CELL CARCINOMA; MUTAGEN SENSITIVITY; MOLECULAR EPIDEMIOLOGY; GENETIC PREDISPOSITION; ATAXIA-TELANGIECTASIA; PEDIGREE ANALYSIS; LUNG-CANCER; RISK; HEAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Braakhuis, BJM Vrije Univ Amsterdam, Univ Hosp, Dept Otorhinolaryngol Head& Neck Surg, POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
J. Cloos et al., "Inherited susceptibility to bleomycin-induced chromatid breaks in culturedperipheral blood lymphocytes", J NAT CANC, 91(13), 1999, pp. 1125-1130

Abstract

Background: Susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes may reflect the way a person deals with carcinogenic challenges. This susceptibility (also referred to as mutagen sensitivity) has been found to be increased in patients with environmentally related cancers, including cancers of the head and neck, lung, and colon, and, in combination with carcinogenic exposure, this susceptibility can greatly influence cancer risk. The purpose of this study was to assess the heritability of mutagen sensitivity. Methods: Heritability was determined by use of a maximum likelihood method that employed the FISHER package of pedigreeanalysis. Bleomycin-induced breaks per cell values for 135 healthy volunteers without cancer were determined, These individuals were from 53 different pedigrees and included 25 monozygotic twin pairs (n = 50), 14 pairs of dizygotes (twin pairs and siblings, n = 28), and 14 families selected on the basis of a first-degree relative who was successfully treated for head and neck cancer and who had no sign of recurrence for at least 1 year. All datawere analyzed simultaneously, and different models of familial resemblancewere fitted to the data. All P values are two-sided, Results: Our results showed no evidence for the influence of a shared family environment on bleomycin-induced chromatid breaks. Genetic influences, however, were statistically significant (P = .036) and accounted for 75% of the total variance. Conclusions: The high heritability estimate of the susceptibility to bleomycin-induced chromatid breaks indicates a clear genetic basis. The findings ofthis study support the notion that a common genetic susceptibility to DNA damage-and thereby a susceptibility to cancer-may exist in the general population.

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Documento generato il 24/01/20 alle ore 12:45:09