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Titolo:
Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil
Autore:
Ellis, CM; Monk, C; Simmons, A; Lemmens, G; Williams, SCR; Brammer, M; Bullmore, E; Parkes, JD;
Indirizzi:
Inst Psychiat, Dept Clin Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF n Neurosci, London SE5 8AF, England Maudsley Hosp, Dept Neuroimaging, London SE5 8AZ, England Maudsley Hosp London England SE5 8AZ uroimaging, London SE5 8AZ, England Inst Psychiat, Brain Image Anal Unit, London SE5 8AF, England Inst Psychiat London England SE5 8AF Anal Unit, London SE5 8AF, England
Titolo Testata:
JOURNAL OF SLEEP RESEARCH
fascicolo: 2, volume: 8, anno: 1999,
pagine: 85 - 93
SICI:
0962-1105(199906)8:2<85:FMRINS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; AMPHETAMINE; ACTIVATION; SLEEP;
Keywords:
fMRI; modafinil; narcoleptic syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Parkes, JD Inst Psychiat, Dept Clin Neurosci, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF , England
Citazione:
C.M. Ellis et al., "Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil", J SLEEP RES, 8(2), 1999, pp. 85-93

Abstract

Functional magnetic resonance imaging (RMRI) can be used to detect regional brain responses to changes in sensory stimuli. We have used fMRI to determine the amount of visual and auditory cortical activation in 12 normal subjects and 12 subjects with the narcoleptic syndrome, using a multiplexed visual and auditory stimulation paradigm. In both normal and narcoleptic subjects, mean cortical activation levels during the presentation of periodic visual and auditory stimulation showed no appreciable differences with either age or sex. Normal subjects showed higher levels of visual activation at 10:00 hours than 15:00 hours, with a reverse pattern in narcoleptic subjects (P=0.007). The group differences in spatial extent of cortical activationbetween control and narcoleptic subjects were small and statistically insignificant. The alerting action, and imaging response, to a single oral doseof the sleep-preventing drug modafinil 400 mg were then determined and compared with placebo in both the 12 normal (8 given modafinil, 4 placebo) and12 narcoleptic subjects (8 modafinil, 4 placebo). Modafinil caused an increase in self-reported levels of alertness in 7 of 8 narcoleptic subjects, but there was no significant difference between mean pretreatment and post-treatment activation levels as determined by fMRI for either normal or narcoleptic syndrome subjects given modafnnil. However, in the modafinil-treatedgroup of 8 normal and 8 narcoleptic subjects, there was a clock time independent correlation between the initial level of activation as determined bythe pretreatment scan and the post-treatment change in activation (visual,P=0.002; and auditory, P=0.001). No correlation was observed in placebo-treated subjects (P=0.99 and 0.77, respectively). Although limited by the small number of subjects, and the lack of an objective measure of alertness, the findings of this study suggest that low cortical activation levels in both normal and narcoleptic subjects are increased following the administration of modafinil. Functional magnetic resonance imaging may be a valuable addition to established studies of attention.

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Documento generato il 06/04/20 alle ore 05:09:02