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Titolo:
GHRP-6 in heifer and cow adenohypophisial cells separated by elutriation
Autore:
Rico, M; Lorenzo, MT; Pazo, JA; Vega, FV; De la Cruz, LF;
Indirizzi:
Univ Santiago de Compostela, Fac Vet, Dept Fisiol, Lugo 27002, Spain Univ Santiago de Compostela Lugo Spain 27002 t Fisiol, Lugo 27002, Spain Univ Santiago de Compostela, Fac Vet, Dept Anat & Prod Anim, Lugo 27002, Spain Univ Santiago de Compostela Lugo Spain 27002 rod Anim, Lugo 27002, Spain
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 1, volume: 55, anno: 1999,
pagine: 33 - 39
SICI:
1138-7548(199903)55:1<33:GIHACA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR-PITUITARY-CELLS; HORMONE (GH)-RELEASING PEPTIDE; STIMULATE GH RELEASE; GROWTH-HORMONE; CENTRIFUGAL ELUTRIATION; RAT; SOMATOTROPHS; HEXAPEPTIDE; SECRETION; BOVINE;
Keywords:
GH; GHRP-6; GHRH; cultures; bovine; mammosomatotropes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: De la Cruz, LF Univ Santiago de Compostela, Fac Vet, Dept Fisiol, Lugo 27002, Spain Univ Santiago de Compostela Lugo Spain 27002 27002, Spain
Citazione:
M. Rico et al., "GHRP-6 in heifer and cow adenohypophisial cells separated by elutriation", J PHYSIOL B, 55(1), 1999, pp. 33-39

Abstract

Previous studies have reported that the growth hormone (GH)-releasing peptide (GHRP-6), a synthetic Met-enkephalin peptide analog, stimulates GH release in vivo in a variety of species, including bovine. In the present study, the in vitro effects of GHRP-6 on bovine somatotropes separated by elutriation were analyzed as well as its interactions with the GH-releasing hormone (GHRH). The administration of GHRP-6 at doses from 10(-8) M to 10(-5) M stimulated GH release, and also 10(-9) M in cow pituitary cells, and produced maximal stimulation at 10(-6) M. The effects of GHRP-6 (10(-6) M) on GH release were shown at 1, 2, 3 and 4-h incubation (p < 0.05), except for heifer pituitary cells at 1-h incubation (p > 0.05). The GH releasing effects of either GHRH alone or GHRH+GHRP-6 were significantly more potent than that of GHRP-6 alone (p < 0.05). Contrary to what ocurred in rat pituitary cells, the combined administration of 10(-6) M GHRP-6 with 10(-8) M GHRH did not result in a synergist action of GH release. Although the additive effectwas significant when compared with GHRH alone (p < 0.05). The results demonstrate the existence of differences in the effect of GHRH+GHRP-6 on bovinesomatotropes. These differences may reflect the physiological importance of distinct cell subpopulation, like the mammosomatotroph cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:22:00