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Titolo:
Cluster versus conventional immunotherapy in patients allergic to Dermatophagoides pteronyssinus: A controlled study of in vivo and in vitro parameters
Autore:
Muro, MD; Tabar, AI; Lizaso, MT; Quirce, S; Polo, F; Garcia, BE;
Indirizzi:
Hosp Virgen Camino, Allergol Sect, Pamplona, Spain Hosp Virgen Camino Pamplona Spain amino, Allergol Sect, Pamplona, Spain
Titolo Testata:
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 9, anno: 1999,
pagine: 146 - 154
SICI:
1018-9068(199905/06)9:3<146:CVCIIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONJUNCTIVAL PROVOCATION TEST; SUBCLASS ANTIBODY-RESPONSE; YELLOW JACKET VENOM; DOUBLE-BLIND; MONOCLONAL-ANTIBODIES; POLLEN; EXTRACTS; IGE; EFFICACY; ASTHMA;
Keywords:
cluster schedule; conjunctival provocation test; Dermatophagoides pteronyssinus; immunotherapy; in vitro parameters; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tabar, AI Ambulatorio Conde Oliveto, Secc Alergol, Plaza Paz S-N, Pamplona31002, Spain Ambulatorio Conde Oliveto Plaza Paz S-N Pamplona Spain 31002in
Citazione:
M.D. Muro et al., "Cluster versus conventional immunotherapy in patients allergic to Dermatophagoides pteronyssinus: A controlled study of in vivo and in vitro parameters", J INVES ALL, 9(3), 1999, pp. 146-154

Abstract

We designed a cluster schedule of immunotherapy for patients allergic to Dermatophagoides pteronyssinus which showed good safety and clinical efficacy. Here we compare the in vivo and in vitro changes with those of a conventional schedule in a controlled trial Sixty-three patients were randomized as follows: 29 were treated with the cluster schedule, 15 with a conventional schedule and 19 received no immunotherapy. A standardized extract was used. Changes in in vivo parameters (skin prick test and conjunctival provocation test) and in in vitro parameters (IgE, IgG, IgG1 and IgG4 for the complete extract, Der p 1 and Der p 2) were measured before immunotherapy (T-0),on reaching maintenance phase (T-1), and after 6 (T-2), 12 (T-3) and 18 months of maintenance (T-4). Cutaneous reactivity showed a significant decrease from T-1 in both the cluster and conventional schedules, and conjunctival reactivity was also significantly lowered from T-1 in these groups. Specific IgE decreased and specific IgG, IgG1 and IgG4 increased significantly from T-1 in the cluster and conventional schedules. Neither of these parameters showed any changes in the group without immunotherapy. In conclusion, our cluster schedule induced changes in cutaneous and conjunctival reactivity and in immunological parameters that were similar to those achieved with the conventional schedule; these changes did not appear in patients who didnot undergo immunotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:04:52