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Titolo:
Clonidine: Applications in the pediatric neurosurgical patient
Autore:
Tobias, JD;
Indirizzi:
Univ Missouri, Dept Child Hlth, Hlth Sci Ctr M658, Div Pediat Crit Care Pediat Anesthesiol, Columbia, MO 65212 USA Univ Missouri Columbia MO USA 65212 t Anesthesiol, Columbia, MO 65212 USA Univ Missouri, Dept Anesthesiol, Columbia, MO 65212 USA Univ Missouri Columbia MO USA 65212 t Anesthesiol, Columbia, MO 65212 USA
Titolo Testata:
JOURNAL OF INTENSIVE CARE MEDICINE
fascicolo: 4, volume: 14, anno: 1999,
pagine: 200 - 203
SICI:
0885-0666(199907/08)14:4<200:CAITPN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAD-INJURED PATIENTS; CEREBRAL HEMODYNAMICS; ANESTHESIA; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tobias, JD Univ Missouri, Dept Child Hlth, Hlth Sci Ctr M658, Div Pediat Crit Care Pediat Anesthesiol, 1 Hosp Dr, Columbia, MO 65212 USA Univ Missouri 1 Hosp Dr Columbia MO USA 65212 bia, MO 65212 USA
Citazione:
J.D. Tobias, "Clonidine: Applications in the pediatric neurosurgical patient", J INTENS C, 14(4), 1999, pp. 200-203

Abstract

Clonidine's antihypertensive effects result ham the activation of central alpha(2)-adrenergic receptors. This results in a de crease in sympathetic or vasomotor tone from the medulla and a decrease in heart rate and systemicvascular resistance. Despite reports of its use in the pediatric population as a premedicant for the operating room, as an adjunct to caudal epiduralanesthesia, to supplement opioid analgesia, and to treat behavioral disorders, there is Limited experience with its use as an antihypertensive agent in children. The author describes his experience with clonidine to control mean arterial pressure in three pediatric neurosurgical patients when otheroptions for oral therapy including angiotensin converting enzyme (ACE) inhibitors, beta-adrenergic antagonists, and calcium channel antagonists proved to be ineffective. Previous experience with clonidine as an antihypertensive agent in children is reviewed and recommendations made concerning possible dosing regimens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:14:14