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Titolo:
Immune system development and function in prolactin receptor-deficient mice
Autore:
Bouchard, B; Ormandy, CJ; Di Santo, JP; Kelly, PA;
Indirizzi:
Fac Med Necker, INSERM U344, F-75730 Paris 15, France Fac Med Necker Paris France 15 er, INSERM U344, F-75730 Paris 15, France Garvan Inst Med Res, Canc Res Program, Sydney, NSW, Australia Garvan Inst Med Res Sydney NSW Australia Program, Sydney, NSW, Australia Hop Necker Enfants Malad, INSERM U429, Paris, France Hop Necker Enfants Malad Paris France Malad, INSERM U429, Paris, France
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 163, anno: 1999,
pagine: 576 - 582
SICI:
0022-1767(19990715)163:2<576:ISDAFI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACENTAL-LACTOGEN RECEPTOR; GROWTH-HORMONE; LYMPHOCYTE-T; BROMOCRIPTINE TREATMENT; SIGNAL-TRANSDUCTION; CELL DEVELOPMENT; HYPERPROLACTINEMIA; PROTEINS; MOUSE; NK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, PA Fac Med Necker, INSERM U344, F-75730 Paris 15, France Fac Med Necker Paris France 15 U344, F-75730 Paris 15, France
Citazione:
B. Bouchard et al., "Immune system development and function in prolactin receptor-deficient mice", J IMMUNOL, 163(2), 1999, pp. 576-582

Abstract

Prolactin (PRL) is the primary lactogenic pituitary hormone that plays an essential role in many aspects of reproduction, from fertilization to mammary gland development and maternal behavior. PRL has also been reported to play a role in immunoregulation, Because initial observations indicated thathypophysectomized rats present abnormalities of the immune system, including increased thymic atrophy and lymphopenia, a number of studies have focused on the potential immunomodulatory roles of PRL, This hormone exerts its biological activities following binding to specific cell surface PRL receptors (PRLRs), In this report, we have characterized the development and function of the immune system in PRLR-deficient mice. Compared with wild-type control mice, PRLR-/- mice demonstrate no alterations in thymic or splenic cellularity or in the composition of the lymphocyte subsets present in primary (bone marrow and thymus) or secondary (spleen and lymph nodes) lymphoid organs. Lymphocytes from PRLR-/- mice are functional in vitro, as they can proliferate normally to mitogens, cytokines, and allogeneic cells. PRLR-/- splenocytes display normal NK-mediated cytotoxicity to YAC-1 target cells. In vivo studies have revealed that PRLR-/- mice are able to 1) generate normal steady-state Ig levels, 2) mount a normal specific Ig response following immunization with a T-dependent Ag, 3) eliminate injected allogeneic tumor cells, and 3) effectively control Listeria monocytogenes infection. Takentogether, these results show that immune system development and function proceed normally in the absence of PRL-mediated signaling and suggest that PRLR pathways are not essential for immunomodulation in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:06:16