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Titolo:
Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex
Autore:
Aifantis, I; Feinberg, J; Fehling, HJ; Di Santo, JP; von Boehmer, H;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U373, Inst Necker, F-75730 Paris 15, France Hop Necker Enfants Malad Paris France 15 ecker, F-75730 Paris 15, France INSERM U429, CH-4005 Basel, Switzerland INSERM U429 Basel Switzerland CH-4005 M U429, CH-4005 Basel, Switzerland Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 1, volume: 190, anno: 1999,
pagine: 141 - 144
SICI:
0022-1007(19990705)190:1<141:ETCRBG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPMENT IN-VIVO; ALPHA-BETA; CHAIN; MICE; REARRANGEMENT; LYMPHOCYTES; THYMOCYTES; SURFACE;
Keywords:
lymphocyte development; pre-T cell receptor; cytoplasmic T cell receptor beta; clonotype-independent CD3 complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: von Boehmer, H Hop Necker Enfants Malad, INSERM, U373, Inst Necker, 156 Rue Vaugirard, F-75730 Paris 15, France Hop Necker Enfants Malad 156 Rue Vaugirard Paris France 15
Citazione:
I. Aifantis et al., "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex", J EXP MED, 190(1), 1999, pp. 141-144

Abstract

We have examined the question of whether there is an additional checkpointin T cell development that regulates T cell receptor (TCR)-beta expressionin CD25(+)44(-) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-beta expression can be accounted for by pre-TCR-dependent signalmediation, putting into question the function of a putative pro-TCR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 20:45:58