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Titolo:
Chronic and acute exercise do not alter Ca2+ regulatory systems and ectonucleotidase activities in rat heart
Autore:
Delgado, J; Saborido, A; Moran, M; Megias, A;
Indirizzi:
Univ Complutense, Dept Bioquim & Biol Mol 1, Fac Biol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 1, Fac Biol, E-28040 Madrid, Spain Univ Complutense, Dept Bioquim & Biol Mol 1, Fac Chem, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 1, Fac Chem, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 87, anno: 1999,
pagine: 152 - 160
SICI:
8750-7587(199907)87:1<152:CAAEDN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC SARCOPLASMIC-RETICULUM; GASTROCNEMIUS-MUSCLE; CONTRACTILE PROTEINS; SKELETAL-MUSCLE; CALCIUM-UPTAKE; ADAPTATION; MYOCARDIUM; TRANSPORT; RYANODINE; RECEPTORS;
Keywords:
calcium channels; sarcoplasmic reticulum calcium-adenosine; 5 '-triphosphatase; 5 '-nucleotidase; physical training; myocardial; adaptation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Megias, A Univ Complutense, Dept Bioquim & Biol Mol 1, Fac Biol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 l, E-28040 Madrid, Spain
Citazione:
J. Delgado et al., "Chronic and acute exercise do not alter Ca2+ regulatory systems and ectonucleotidase activities in rat heart", J APP PHYSL, 87(1), 1999, pp. 152-160

Abstract

The purpose of this investigation was to examine the effects of chronic and acute exercise on the main components involved in excitation-contraction coupling and relaxation in rat heart. Sixty male Wistar rats were divided into a sedentary (S) and three 12-wk treadmill-trained groups (T-l, moderateintensity; T-2, high intensity; T-3, interval running). After 12-wk, 15 rats from the S group and 15 rats from the T-2 group were subjected to a single treadmill-exercise session until exhaustion before being killed at 0, 24, or 48 h (acute exercise). The remaining animals were killed 48 h after the last standard exercise session (chronic exercise). The efficacy of the training programs was confirmed by an increase in treadmill endurance time and in skeletal muscle citrate synthase activity. None of the exercise programs modified heart weight or cardiac oxidative capacity. [H-3]PN200-110 and [H-3]ryanodine binding to cardiac homogenates indicated that the density ofL-type and sarcoplasmic reticulum (SR) Ca2+ channels was the same in S andtrained rats. The SR Ca2+-ATPase activity was also unmodified. Finally, the activities of the ectoenzymes Mg2+-ATPase and 5'-nucleotidase, which are involved in degradation of extracellular nucleotides, were not affected by either of the running programs. After the acute exercise session, no changes were detected in either of the tested parameters in heart homogenates of S and T-2 animals. We conclude that neither treadmill-exercise training for12 wk nor exhaustive exercise alters the density of Ca2+ channels involvedin excitation-contraction coupling or the SR Ca2+-ATPase and the ectonucleotidase activities in rat heart.

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Documento generato il 28/03/20 alle ore 14:20:43