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Titolo:
Influence of nitric oxide on vascular resistance and muscle mechanics during tetanic contractions in situ
Autore:
Ameredes, BT; Provenzano, MA;
Indirizzi:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Sch Med, Pittsburgh, PA15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Sch Med, Pittsburgh, PA15261 USA Univ Pittsburgh, Dept Cell Biol & Physiol, Sch Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Sch Med, Pittsburgh, PA 15261 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 87, anno: 1999,
pagine: 142 - 151
SICI:
8750-7587(199907)87:1<142:IONOOV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED VASODILATION; SKELETAL-MUSCLE; BLOOD-FLOW; RELAXING FACTOR; FUNCTIONAL HYPEREMIA; L-ARGININE; IN-SITU; ENDOTHELIUM; FATIGUE; RELEASE;
Keywords:
canine; endothelium-derived relaxation factor; fatigue; gastrocnemius muscle; hyperemia; intramuscular pressure; passive tension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ameredes, BT Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Sch Med, 440 Scaife Hall,3550 Terrace St, Pittsburgh, PA 15261 USA Univ Pittsburgh 440 Scaife Hall,3550 Terrace St Pittsburgh PA USA 15261
Citazione:
B.T. Ameredes e M.A. Provenzano, "Influence of nitric oxide on vascular resistance and muscle mechanics during tetanic contractions in situ", J APP PHYSL, 87(1), 1999, pp. 142-151

Abstract

Studies of the effect of nitric oxide (NO) synthesis inhibition were performed in the isometrically contracting blood-perfused canine gastrocnemius-plantaris muscle group. Muscle blood flow (Q) was controlled with a pump during continuous NO blockade produced with either 1 mM L-argininosuccinic acid (L-ArgSA) or N-G-nitro-L-arginine methyl ester (L-NAME) during repetitivetetanic contractions (50-Hz trains, 200-ms duration, 1/s). Pump Q was set to match maximal spontaneous Q (1.3-1.4 ml.min(-1).g(-1)) measured in prior, brief (3-5 min) control contraction trials in each muscle. Active tensionand oxygen uptake were 500-600 g/g and 200-230 mu l.min(-1).g(-1), respectively, under these conditions. Within 3 min of L-ArgSA infusion, vascular resistance across the muscle (R-v) increased significantly (from similar to 100 to 300 peripheral resistance units; P < 0.05), whereas R-v increased toa lesser extent with L-NAME (from similar to 100 to 175 peripheral resistance units; P < 0.05). The increase in R-v with L-ArgSA was unchanged by simultaneous infusion of 0.5-10 mM L-arginine but was reduced with 1-3 mu g/mlsodium nitroprusside (41-54%). The increase in R-v with L-NAME was reversed with 1 mM of L-arginine. Increased fatigue occurred with infusion of L-ArgSA; active tension and intramuscular pressure decreased by 62 and 66%, whereas passive tension and baseline intramuscular pressure increased by 80 and 30%, respectively. These data indicate a possible role for NO in the control of R-v and contractility within the canine gastrocnemius-plantaris muscle during repetitive tetanic contractions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:44:54