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Titolo:
Design and experimental validation of a quantitative myocardial Tl-201 SPECT system
Autore:
Iida, H; Shoji, Y; Sugawara, S; Kinoshita, T; Tamura, Y; Narita, Y; Eberl, S;
Indirizzi:
Res Inst Brain & Blood Vessels Akita, Akita 0100874, Japan Res Inst Brain & Blood Vessels Akita Akita Japan 0100874 0100874, Japan Royal Prince Alfred Hosp, Camperdown, NSW 2050, Australia Royal Prince Alfred Hosp Camperdown NSW Australia 2050 SW 2050, Australia
Titolo Testata:
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
fascicolo: 3, volume: 46, anno: 1999,
parte:, 2
pagine: 720 - 726
SICI:
0018-9499(199906)46:3<720:DAEVOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCATTER CORRECTION METHODS; LINE SOURCE; ATTENUATION COMPENSATION; NOISE PROPERTIES; MONTE-CARLO; BLOOD-FLOW; EMISSION; RECONSTRUCTION; ACCURACY; MAPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Iida, H Res Inst Brain & Blood Vessels Akita, Akita 0100874, Japan Res Inst Brain & Blood Vessels Akita Akita Japan 0100874 , Japan
Citazione:
H. Iida et al., "Design and experimental validation of a quantitative myocardial Tl-201 SPECT system", IEEE NUCL S, 46(3), 1999, pp. 720-726

Abstract

We have developed a quantitative SPECT system, and evaluated its potentialfor quantitative assessment of bio-physiological functions in the myocardium particularly with Tl-201. Our approach included development of a transmission system that provides accurate attenuation CL maps, and implementationof ordered-subset EM reconstruction with transmission data based attenuation correction in addition to scatter correction using the transmission-dependent convolution subtraction (TDCS) technique. The transmission system wasdesigned using Monte Carlo simulation to minimize the scatter in the transmission projection data while keeping loss of sensitivity minimal, and was attached to an opposing 2-head gamma camera fitted with parallel beam collimators. Observed CI values agreed with the theoretical expected values in both phantoms and human thorax. Phantom experiments with Tl-201 also demonstrated that, with both corrections for attenuation and scatter, observed images were directly proportional to the actual radioactivity distribution forvarious phantom geometries. Attenuation correction without scatter correction improved images in deep structure, but resulted in significant artifacts in the chest phantom in addition to dependency of observed radioactivity concentrations on the diameter of cylindrical phantoms. Absolute quantitation of bio-physiological functions, which is well established in PET, is shown to be feasible using SPECT, if both quantitative attenuation and scattercorrections are employed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:58:08