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Titolo:
Bcl-6 and bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: Correlation with 3q27 and 18q21 chromosomal abnormalities
Autore:
Skinnider, BF; Horsman, DE; Dupuis, B; Gascoyne, RD;
Indirizzi:
British Columbia Canc Agcy, Dept Pathol, Vancouver, BC V5Z 4E6, Canada British Columbia Canc Agcy Vancouver BC Canada V5Z 4E6 BC V5Z 4E6, Canada British Columbia Canc Agcy, Dept Lab Med, Vancouver, BC V5Z 4E6, Canada British Columbia Canc Agcy Vancouver BC Canada V5Z 4E6 BC V5Z 4E6, Canada Univ British Columbia, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 7, volume: 30, anno: 1999,
pagine: 803 - 808
SICI:
0046-8177(199907)30:7<803:BABPEI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; GERMINAL-CENTER FORMATION; PROGNOSTIC-SIGNIFICANCE; GENE REARRANGEMENT; SOMATIC HYPERMUTATION; HIGH-GRADE; REGION; TISSUE; CONFIGURATION; INFLAMMATION;
Keywords:
lymphoma; bcl-2; bcl-6; chromosome 3; chromosome 18;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gascoyne, RD British Columbia Canc Agcy, Dept Pathol, 600 W 10th Ave, Vancouver, BC V5Z4E6, Canada British Columbia Canc Agcy 600 W 10th Ave Vancouver BC Canada V5Z 4E6
Citazione:
B.F. Skinnider et al., "Bcl-6 and bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: Correlation with 3q27 and 18q21 chromosomal abnormalities", HUMAN PATH, 30(7), 1999, pp. 803-808

Abstract

The bcl-2 gene on chromosome 18 at q21 and the bcl-6 gene on chromosome 3 at q27 are both highly regulated during B-cell differentiation and show an inverse relationship of expression in the normal secondary lymphoid follicle. The objective of this study was to investigate the relationship between bcl-2 and bcl-6 protein expression and the relationship between protein expression and the corresponding chromosomal alterations in malignant lymphomas, including those associated with the germinal center. Expression of bcl-2and bcl-6 proteins was studied in 55 cases of diffuse large B-cell lymphoma (DLBCL) and 21 cases of follicular lymphoma (FL), and the results correlated with the presence of t(14;18) and 3q27 abnormalities in a subset of 52 cases with cytogenetic analysis. These cases were selected to represent a spectrum of nodal and extranodal lymphomas, including those with and withouta t(14;18), It was shown that the neoplastic cells in 71% of DLBCLs and 100% of FLs expressed bcl-6 protein. Expression of bcl-6 was seen more frequently in diffuse large B-cell lymphomas with large noncleaved morphology compared with immunoblastic morphology (82% v 27%, P = .0015), but failed to correlate with 3q27 abnormalities, Thirty-eight percent of cases with 3q27 abnormalities were bcl-6 protein negative, whereas 85% of cases without a 3q27 abnormalities were bcl-6 protein positive. Expression of bcl-2 protein was shown in 51% DLBCLs (nodal v extranodal, 71% v 30%, P = .012). bcl-2 protein was expressed in 89% of FLs with t(14;18), in contrast to 25% of FLs, without t(14;18) (P = .016). In DLBCL and FL with t(14;18), the most commonpattern of expression was bcl-2(+)/bcl-6(+). In lymphomas without t(14;18), there was not an inverse relationship between bcl-2 and bcl-6 protein expression. In conclusion, these data suggest that mechanisms other than gene rearrangements can deregulate bcl-2 and bcl-6 expression in lymphomas, and there does not appear to be an inverse relationship between these two proteins as seen in the normal germinal center. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:42:26