Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
bcl-2 gene therapy exacerbates excitotoxicity
Autore:
Simon, PD; Vorwerk, CK; Mansukani, SS; Chen, SJ; Wilson, JM; Zurakowski, D; Bennett, J; Dreyer, EB;
Indirizzi:
Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 phthalmol, Philadelphia, PA 19104 USA Univ Penn, Inst Human Gene Therapy, Dept Cellular & Mol Engn, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Mol Engn, Philadelphia, PA 19104 USA Childrens Hosp, Dept Biostat, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 sp, Dept Biostat, Boston, MA 02115 USA
Titolo Testata:
HUMAN GENE THERAPY
fascicolo: 10, volume: 10, anno: 1999,
pagine: 1715 - 1720
SICI:
1043-0342(19990701)10:10<1715:BGTEE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; IN-VIVO; PHOTORECEPTOR DEGENERATION; NEUROTROPHIC FACTOR; VIRAL VECTORS; NITRIC-OXIDE; NERVOUS-SYSTEM; ION-CHANNEL; DEATH; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dreyer, EB Univ Penn, Scheie Eye Inst, Dept Ophthalmol, 51 N 39th St, Philadelphia, PA 19104 USA Univ Penn 51 N 39th St Philadelphia PA USA 19104 , PA 19104 USA
Citazione:
P.D. Simon et al., "bcl-2 gene therapy exacerbates excitotoxicity", HUM GENE TH, 10(10), 1999, pp. 1715-1720

Abstract

The protooncogene bcl-2 can block neuronal death from both naturally occurring apoptosis and exogenous insults. bcl-2 is therefore a promising candidate for the prevention of excitotoxic neuronal death. Using an adeno-associated viral vector, we delivered the bcl-2 gene to the ganglion cell layer of the rat eye. We hypothesized that infection with bcl-2 would protect ganglion cells against excitotoxic cell death. However, retinal infection with bcl-2 increased ganglion cell susceptibility to both axonal injury and intravitreal NMDA. Our study-intended to explore the possibility of bcl-2 transduction as an in vivo therapeutic approach-revealed deleterious effect of bcl-2 transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:42:59