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Titolo:
Decrease of serum endothelin levels with postmenopausal hormone replacement therapy or tibolone
Autore:
Haenggi, W; Bersinger, NA; Mueller, MD; Birkhaeuser, MH;
Indirizzi:
Univ Bern, Dept Obstet & Gynecol, CH-3000 Bern, Switzerland Univ Bern Bern Switzerland CH-3000 & Gynecol, CH-3000 Bern, Switzerland
Titolo Testata:
GYNECOLOGICAL ENDOCRINOLOGY
fascicolo: 3, volume: 13, anno: 1999,
pagine: 202 - 205
SICI:
0951-3590(199906)13:3<202:DOSELW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
WOMEN; ESTROGEN;
Keywords:
endothelin; menopause; hormone replacement therapy; 17 beta-estradiol; dydrogesterone; tibolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Haenggi, W Univ Bern, Inselspital, Frauenklin, Schanzeneckstr 1, CH-3012 Bern, Switzerland Univ Bern Schanzeneckstr 1 Bern Switzerland CH-3012 witzerland
Citazione:
W. Haenggi et al., "Decrease of serum endothelin levels with postmenopausal hormone replacement therapy or tibolone", GYNECOL END, 13(3), 1999, pp. 202-205

Abstract

Endothelin is the most potent vasoconstrictor peptide known to date. Hormone replacement therapy (HRT) with estrogen reduces plasma endothelin levels. We measured endothelin in 51 postmenopausal patients before and during HRT. Patients were randomly allocated to receive either oral tibolone, oral or transdermal 17 beta-estradiol. A group of comparable volunteers served ascontrols. After 24 months, endothelin levels decreased in all treatment groups: tibolone, 18.2%; oval 23.1%; transdermal, 20.8%. Endothelin levels increased in the controls by 36.6% (p < 0.01). Tibolone decreases endothelin levels to a similar degree as conventional estrogen-progestogen-replacementtherapy. These data provide another potential mechanism supporting the cardioprotective effects of tibolone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:27:08