Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats
Autore:
Tagliati, CA; Kimura, E; Nothenberg, MS; Santos, SRJC; Oga, S;
Indirizzi:
Univ Sao Paulo, Fac Ciecias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Anal Clin & Toxicol, Sao Paulo, Brazil Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Farmaceut, Dept Farm, Sao Paulo, Brazil Univ Estadual Maringa, Dept Farm & Farmacol, Maringa, Parana, Brazil Univ Estadual Maringa Maringa Parana Brazil col, Maringa, Parana, Brazil Univ Fed Minas Gerais, Fac Farm, Dept Anal Clin & Toxicol, Belo Horizonte,MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil Belo Horizonte,MG, Brazil
Titolo Testata:
GENERAL PHARMACOLOGY
fascicolo: 1, volume: 33, anno: 1999,
pagine: 67 - 71
SICI:
0306-3623(199907)33:1<67:PPAAGE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ACEXAMATE; PROSTAGLANDIN-E2; SULFATE; DOG;
Keywords:
zinc-piroxicam; pharmacokinetics; gastrotoxicity; carrageenin-induced edema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Oga, S Univ Sao Paulo, Fac Ciecias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil lin & Toxicol, Sao Paulo, Brazil
Citazione:
C.A. Tagliati et al., "Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats", GEN PHARM, 33(1), 1999, pp. 67-71

Abstract

Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam an the gastric mucosa. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:23:12