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Titolo:
Markers of fibrinolytic potency and clotting activation in stable angina pectoris: role of urokinase, assessment of atrioventricular differences and correlation with coronary patency
Autore:
Paramo, JA; Panizo, C; Montes, R; Orbe, J; Alegria, E; Martinez-Caro, D; Dooijewaard, G;
Indirizzi:
Univ Navarra, Sch Med, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 ra, Sch Med, E-31080 Pamplona, Spain Univ Navarra, Sch Med, Lab Vasc Biol & Thrombosis Res, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 ombosis Res, E-31080 Pamplona, Spain Univ Clin, Dept Cardiol, Pamplona, Spain Univ Clin Pamplona SpainUniv Clin, Dept Cardiol, Pamplona, Spain TNO PG, Gaubius Lab, Leiden, Netherlands TNO PG Leiden NetherlandsTNO PG, Gaubius Lab, Leiden, Netherlands
Titolo Testata:
FIBRINOLYSIS & PROTEOLYSIS
fascicolo: 3, volume: 13, anno: 1999,
pagine: 133 - 138
SICI:
1369-0191(199905)13:3<133:MOFPAC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR; ACUTE MYOCARDIAL-INFARCTION; HEART-DISEASE; ARTERY DISEASE; FRAGMENT 1+2; BETA-THROMBOGLOBULIN; FIBRINOPEPTIDE-A; SUDDEN-DEATH; RISK GROUP; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Paramo, JA Univ Navarra, Sch Med, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 , E-31080 Pamplona, Spain
Citazione:
J.A. Paramo et al., "Markers of fibrinolytic potency and clotting activation in stable angina pectoris: role of urokinase, assessment of atrioventricular differences and correlation with coronary patency", FIBRINOL PR, 13(3), 1999, pp. 133-138

Abstract

To characterize the extent of activation of the hemostatic system and to detect local alterations which may favour thrombus formation we obtained samples from the right atrium (RA) and left ventricle (LV) of 60 stable anginapatients (mean age 59 years, M/F: 49/11) during the cardiac catheterization procedure. None of the patients had a recent myocardial infarction or angioplasty. Plasma was prepared from citrated blood samples and the followingparameters were determined: thrombin-antithrombin (TAT) complexes, prothrombin fragment 1+2 (F1+2), plasmin-antiplasmin (PAP) complexes, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1) activity and the levels of both u-PA activity (scu-PA) and antigen (u-PA Ag). Results were correlated with the angiographic findings. The analysis of the different parameters analyzed between patients with coronary stenosis or occlusion in one or more vessels (n=47) and without occlusion (n=13), showed no differences for TAT, PAP, F1+2, and PAI-1 activity between groups. However, a significant increase of t-PA antigen could be demonstrated in patientswith occlusion (10.5+/-4.9 ng/ml) as compared to those with angiographically-verified coronary patency (7.5+/-3.2 ng/ml) (P<0.03), suggesting that t-PA may be a good marker for occlusion in these patients. u-PA results showed the lowest ratio in the more severe patients (59 vs 66%) (P<0.05). The scu-PA/u-PA ratio was also significantly reduced in the sample taken from RA as compared with LV (P<0.001). Our results point to an enhanced local activation of the fibrinolytic system in the more severe patients with stable angina pectoris and to atrioventricular differences in the u-PA components.

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Documento generato il 26/01/20 alle ore 16:58:53