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Titolo:
Melanocortin receptors: perspectives for novel drugs
Autore:
Wikberg, JES;
Indirizzi:
Univ Uppsala, Dept Pharmaceut Pharmacol, SE-75124 Uppsala, Sweden Univ Uppsala Uppsala Sweden SE-75124 Pharmacol, SE-75124 Uppsala, Sweden Melacure Therapeut, SE-75318 Uppsala, Sweden Melacure Therapeut Uppsala Sweden SE-75318 eut, SE-75318 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 375, anno: 1999,
pagine: 295 - 310
SICI:
0014-2999(19990630)375:1-3<295:MRPFND>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING-HORMONE; MESSENGER-RNA EXPRESSION; AGOUTI OBESITY SYNDROME; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; MOLECULAR-CLONING; NEUROPEPTIDE-Y; MSH RECEPTOR; ANOREXIA-NERVOSA;
Keywords:
melanocortin receptor; localization; function; structure; selective drug;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Wikberg, JES Univ Uppsala, Dept Pharmaceut Pharmacol, Box 591 BMC, SE-75124 Uppsala, Sweden Univ Uppsala Box 591 BMC Uppsala Sweden SE-75124 ala, Sweden
Citazione:
J.E.S. Wikberg, "Melanocortin receptors: perspectives for novel drugs", EUR J PHARM, 375(1-3), 1999, pp. 295-310

Abstract

The cloning of bye different subtypes of melanocortin receptor subtypes have recently opened up new possibilities for the development of drugs. The physiological roles of the five melanocortin receptors have started to become understood, and compounds with selective actions on some of the five subtypes have become available. Presently, most clinically promising application for drugs active on melanocortin receptors are for control of feeding homeostasis and body weight and for treatment of inflammatory diseases. I review here the cloning, localisation, function and structure of the melanocortin receptors, in relation to the possibilities to develop selective drugs for these receptors. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 13:40:47