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Titolo:
Lack of effect of propranolol in the prevention of large oesophageal varices in patients with cirrhosis: a randomized trial
Autore:
Cales, P; Oberti, F; Payen, JL; Naveau, S; Guyader, D; Blanc, P; Abergel, A; Bichard, P; Raymond, JM; Canva-Delcambre, V; Vetter, D; Valla, D; Beauchant, M; Hadengue, A; Champigneulle, B; Pascal, JP; Poynard, T; Lebrec, D;
Indirizzi:
Univ Hosp, Dept Hepatogastroenterol, Angers, France Univ Hosp Angers France Hosp, Dept Hepatogastroenterol, Angers, France
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 7, volume: 11, anno: 1999,
pagine: 741 - 745
SICI:
0954-691X(199907)11:7<741:LOEOPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-HYPERTENSION; ESOPHAGEAL-VARICES; PRESSURE; HEMORRHAGE; RATS; HEMODYNAMICS; CIRRHOTICS; FAILURE; PLACEBO; MODEL;
Keywords:
cirrhosis; oesophageal varices; portal hypertension; prevention of variceal bleeding; propranolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Cales, P CHU Angers, F-49033 Angers, France CHU Angers Angers France F-49033 Angers, F-49033 Angers, France
Citazione:
P. Cales et al., "Lack of effect of propranolol in the prevention of large oesophageal varices in patients with cirrhosis: a randomized trial", EUR J GASTR, 11(7), 1999, pp. 741-745

Abstract

Objective beta-blockers have been shown to reduce portal pressure in patients with cirrhosis and limit the development of portosystemic shunts in portal hypertensive animals. Thus, a randomized double-blind trial was conducted to evaluate propranolol in the prevention of the development of large oesophageal varices in patients with cirrhosis without varices or with small varices. Methods One hundred and two patients received long-acting propranolol (160mg/day) and 104 patients received a placebo. At inclusion, there was no significant difference between the two groups in terms of clinical characteristics or biochemical tests. At 2 years, the size of varices was estimated on video recordings. Results One-third of the patients were lost to follow-up, and 95%/97% of the remaining patients were compliant in the propranolol and placebo groups,respectively. At 2 years, the proportion of patients with large varices was 31% in the propranolol group and 14% in the placebo group (P < 0.05). Three and four patients bled in the propranolol and placebo groups, respectively, and nine and ten died, respectively. Conclusion This trial suggests that propranolol administration cannot be recommended for the prevention of the development of large oesophageal varices in patients with cirrhosis; thus other studies are needed in selected subgroups of patients. Eur J Gastroenterol Hepatol 11:741-745 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:28:38