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Titolo:
DNA fingerprinting and molecular epidemiology of tuberculosis: Use and interpretation in an epidemic setting
Autore:
Warren, R; Richardson, M; van der Spuy, G; Victor, T; Sampson, S; Beyers, N; van Helden, P;
Indirizzi:
Univ Stellenbosch, Dept Pediat & Child Hlth, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa Univ Stellenbosch, Dept Biochem Med, MRC, Ctr Cellular & Mol Biol, ZA-7505Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa
Titolo Testata:
ELECTROPHORESIS
fascicolo: 8, volume: 20, anno: 1999,
pagine: 1807 - 1812
SICI:
0173-0835(199906)20:8<1807:DFAMEO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS; TRANSMISSION;
Keywords:
tuberculosis; molecular epidemiology; DNA fingerprinting; disease dynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: van Helden, P Univ Stellenbosch, Dept Pediat & Child Hlth, POB 19063, ZA-7505 Tygerberg,South Africa Univ Stellenbosch POB 19063 Tygerberg South Africa ZA-7505
Citazione:
R. Warren et al., "DNA fingerprinting and molecular epidemiology of tuberculosis: Use and interpretation in an epidemic setting", ELECTROPHOR, 20(8), 1999, pp. 1807-1812

Abstract

Tuberculosis (TB) is still a major cause of morbidity and mortality. It isclear that control requires more than simple availability of antibiotics. In order to gain insight into the disease, DNA fingerprinting has been applied to the study of bacterial population structure. This technology has been used to quantitate various components of the disease in a high-incidence community, viz. recent transmission (RT) and reactivation (RA) and to monitor these over time as a tool to quantitate changes in the epidemic. In our high-incidence community, we find unexpectedly high strain diversity, lowerthan predicted RT, and that reactivation disease dominates. This technology can be used to examine and challenge traditional dogmas. Quantitative measure of RT varies over time, using a two-year sliding window for estimationas a useful period. The results show that the "epidemic" consists of subepidemics characterized by strain families that wax and wane in the communityof TB patients. The technology is shown to be a useful and quantitative tool to assess disease status and can therefore be used to monitor intervention strategies and refine and monitor results of new control measures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:16:39