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Titolo:
FRITZ - A SECRETED FRIZZLED-RELATED PROTEIN THAT INHIBITS WNT ACTIVITY
Autore:
MAYR T; DEUTSCH U; KUHL M; DREXLER HCA; LOTTSPEICH F; DEUTZMANN R; WEDLICH D; RISAU W;
Indirizzi:
MAX PLANCK INST PHYSIOL & CLIN RES,WG KERCKHOFF INST,ABT MOL ZELLBIOL,PK STR 1 D-61231 BAD NAUHEIM GERMANY MAX PLANCK INST PHYSIOL & CLIN RES,WG KERCKHOFF INST,ABT MOL ZELLBIOLD-61231 BAD NAUHEIM GERMANY UNIV ULM,BIOCHEM ABT D-89081 ULM GERMANY MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY UNIV REGENSBURG,INST BIOCHEM GENET & MIKROBIOL D-93040 REGENSBURG GERMANY
Titolo Testata:
Mechanisms of development
fascicolo: 1, volume: 63, anno: 1997,
pagine: 109 - 125
SICI:
0925-4773(1997)63:1<109:F-ASFP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; MAMMARY ONCOGENE INT-1; TRANSMEMBRANE DOMAINS; RETROVIRAL VECTORS; WINGLESS PROTEIN; TISSUE POLARITY; DROSOPHILA; GENE; EXPRESSION; PROTOONCOGENE;
Keywords:
FRITZ; FRIZZLED; WNT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
T. Mayr et al., "FRITZ - A SECRETED FRIZZLED-RELATED PROTEIN THAT INHIBITS WNT ACTIVITY", Mechanisms of development, 63(1), 1997, pp. 109-125

Abstract

Signaling molecules of the Wnt gene family are involved in the regulation of dorso-ventral, segmental and tissue polarity in Xenopus and Drosophila embryos. Members of the frizzed gene family, such as Drosophila frizzled-2 and rat frizzled-1, have been shown to encode Wnt binding activity and to engage intracellular signal transduction molecules known to be part of the Wnt signaling pathway. Here we describe the cloning and characterization of Fritz, a mouse (mfiz) and human (hfiz) gene which codes for a secreted protein that is structurally related to the extracellular portion of the frizzled genes from Drosophila and vertebrates. The Fritz protein antagonizes Wnt function when both proteins are ectopically expressed in Xenopus embryos. In early gastrulation, mouse fiz mRNA is expressed in all three germ layers. Later in embryogenesis fiz mRNA is found in the central and peripheral nervous systems, nephrogenic mesenchyme and several other tissues, all of which aresites where Wnt proteins have been implicated in tissue patterning. We propose a model in which Fritz can interfere with the activity of Wnt proteins via their cognate frizzled receptors and thereby modulate the biological responses to Wnt activity in a multitude of tissue sites. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:55:10