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Titolo:
The roles of Sarcophaga defense molecules in immunity and metamorphosis
Autore:
Natori, S; Shiraishi, H; Hori, S; Kobayashi, A;
Indirizzi:
Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Inst Phys & Chem Res, Wako, Saitama 3520198, Japan Inst Phys & Chem Res Wako Saitama Japan 3520198 o, Saitama 3520198, Japan
Titolo Testata:
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
fascicolo: 4-5, volume: 23, anno: 1999,
pagine: 317 - 328
SICI:
0145-305X(199906/07)23:4-5<317:TROSDM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEREGRINA FLESH-FLY; NF-KAPPA-B; EMBRYONIC-CELL LINE; LECTIN GENE; CDNA CLONING; FAT-BODY; ANTIBACTERIAL PROTEINS; TRANSCRIPTION FACTORS; BACTERICIDAL PROTEIN; HEMOCYTE PROTEINASE;
Keywords:
insect immunity; metamorphosis; antibacterial substance; insect lectin; protease; rel ank family; methylation; self-nonself recognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, A Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 yo 1130033, Japan
Citazione:
S. Natori et al., "The roles of Sarcophaga defense molecules in immunity and metamorphosis", DEV COMP IM, 23(4-5), 1999, pp. 317-328

Abstract

This article summarizes recent progress (1996-1998) in our studies on self-defense molecules in Sarcophaga peregrina. A new antibacterial substance was purified and its unique structure and function revealed a novel aspect of the Sarcophaga defense system. We found anovel lectin and cysteine protease in hemocytes which will assist in the understanding of immune response of hemocytes. There have been two major advances in research on the regulation of defense gene induction: (i) cDNA cloning of a new transcriptional factor binding to the kappa B-like promoter sequence of the Sarcophaga lectin gene, (ii) methylation of cytosolic factors essential for induction of immune genes in the fatbody. Metamorphosis is an interesting event from an immunological point of view:(i) a novel protease with antibacterial activity was discovered from metamorphosing gut, and (ii) a pupal hemocyte-specific surface antigen was purified and characterized in terms of its structure and possible function for larval tissue recognition and elimination. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:29:48