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Titolo:
Hedgehog activates the EGF receptor pathway during Drosophila head development
Autore:
Amin, A; Li, YB; Finkelstein, R;
Indirizzi:
Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neurosci, Philadelphia, PA 19104 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 12, volume: 126, anno: 1999,
pagine: 2623 - 2630
SICI:
0950-1991(199906)126:12<2623:HATERP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUBITUS-INTERRUPTUS PROTEIN; GROWTH-FACTOR RECEPTOR; CELL FATE; MORPHOGENETIC FURROW; VENTRAL ECTODERM; WINGLESS PROTEIN; GENE-EXPRESSION; EYE DEVELOPMENT; IMAGINAL DISK; FEEDBACK LOOP;
Keywords:
hedgehog; vein; epidermal growth factor receptor; Drosophila; head development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Finkelstein, R Univ Penn, Sch Med, Dept Neurosci, 35th St & Hamilton Walk,Philadelphia, PA 19104 USA Univ Penn 35th St & Hamilton Walk Philadelphia PA USA 19104
Citazione:
A. Amin et al., "Hedgehog activates the EGF receptor pathway during Drosophila head development", DEVELOPMENT, 126(12), 1999, pp. 2623-2630

Abstract

The Hedgehog (Hh) and Epidermal growth factor receptor (EGFR) signaling pathways play critical roles in pattern formation and cell proliferation in invertebrates and vertebrates. In this study, we demonstrate a direct link between these two pathways in Drosophila melanogaster. Hh and EGFR signalingare each required for the formation of a specific region of the head of the adult fruitfly, We show that hh and vein (vn), which encodes a ligand of the Drosophila EGFR (Schnepp, B., Grumbling, G., Donaldson, T. and Simcox, A. (1996) Gertes Dev, 10, 2302-13), are expressed in adjacent domains within the imaginal primordium of this region. Using loss- and gain-of-function approaches, we demonstrate that Hh activates vn expression, We also show that Hh activation of vn is mediated through the gene cubitus interruptus (ci) and that this activation requires the C-terminal region of the Ci protein. Finally, we demonstrate that wingless (wg) represses vn expression, thereby limiting the domain of EGFR signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:21:46