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Titolo:
Improvement of impaired myocardial vasodilatation due to diffuse coronary atherosclerosis in hypercholesterolemics after lipid-lowering therapy
Autore:
Yokoyama, I; Momomura, S; Ohtake, T; Yonekura, K; Yang, WD; Kobayakawa, N; Aoyagi, T; Sugiura, S; Yamada, N; Ohtomo, K; Sasaki, Y; Omata, M; Yazaki, Y;
Indirizzi:
Univ Tokyo, Dept Cardiovasc Med, Dept Internal Med 2, Grad Sch Med,Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 d Sch Med,Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Metab Dis, Tokyo 1138655, Japan Univ TokyoTokyo Japan 1138655 Med, Dept Metab Dis, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ch Med, Dept Radiol, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Dept Gastroenterol, Tokyo 1138655, Japan
Titolo Testata:
CIRCULATION
fascicolo: 2, volume: 100, anno: 1999,
pagine: 117 - 122
SICI:
0009-7322(19990713)100:2<117:IOIMVD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; RISK FACTOR MODIFICATION; FLOW RESERVE; YOUNG MEN; FAMILIAL HYPERCHOLESTEROLEMIA; PERFUSION ABNORMALITIES; DIABETES-MELLITUS; ARTERY DISEASE; BYPASS GRAFTS; N-13 AMMONIA;
Keywords:
cholesterol; hyperlipidemia; lipid-lowering therapy; blood flow reserve; tomography, emission-computed;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, I Univ Tokyo, Dept Cardiovasc Med, Dept Internal Med 2, Grad SchMed,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 kyo 1138655, Japan
Citazione:
I. Yokoyama et al., "Improvement of impaired myocardial vasodilatation due to diffuse coronary atherosclerosis in hypercholesterolemics after lipid-lowering therapy", CIRCULATION, 100(2), 1999, pp. 117-122

Abstract

Background-Diminished myocardial vasodilatation (MVD) in hypercholesterolemics without overt coronary stenosis has been reported. However, whether the diminished MVD of angiographically normal coronary arteries in hypercholesterolemics can be reversed after lipid-lowering therapy is not known,Methods and Results-A total of 27 hypercholesterolemics and 16 age-matchedcontrols were studied. All patients had >1 normal coronary artery, and those segments that were perfused by anatomically normal coronary arteries were studied, Myocardial blood flow (MBF) was measured during dipyridamole loading and at baseline using positron emission tomography and N-13-ammonia, after which MVD was calculated before and after lipid-lowering therapy. Total cholesterol was significantly higher in hypercholesterolemics (263+/-33.8) than in controls (195+/-16.6), and it normalized after lipid-lowering therapy (197+/-19.9). Baseline MBF (ml.min(-1).100 g(-1)) was comparable amonghypercholesterolemics (both before and after therapy) and controls. MBF during dipyridamole loading was significantly lower in hypercholesterolemics before therapy (189+/-75.4) than in controls (299+/-162, P<0.01), However, MBF during dipyridamole loading significantly increased after therapy (226+/-84.7; P<0.01). MVD significantly improved after therapy in hypercholesterolemics (2.77+/-1.35 after treatment [P<0.05] versus 2.02+/-0.68 before treatment [P<0.01]), but it remained significantly higher in controls (3.69+/-1.13, P<0.01). There was a significant relationship between the percent change of total cholesterol and the percent change of MVD before and after lipid-lowering therapy (r=-0.61, P<0.05). Conclusions-Diminished MVD of anatomically normal coronary arteries in hypercholesterolemics can be reversed after lipid-lowering therapy.

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Documento generato il 18/01/20 alle ore 02:03:38