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Titolo:
Raphe serotonergic neurons projecting to the olfactory bulb contain galanin or somatostatin but not neurotensin
Autore:
Araneda, S; Gysling, K; Calas, A;
Indirizzi:
Univ Lyon 1, Fac Med, INSERM U480, Dept Expt Med, F-69373 Lyon 8, France Univ Lyon 1 Lyon France 8 RM U480, Dept Expt Med, F-69373 Lyon 8, France Catholic Univ Chile, Dept Cell & Mol Biol, Santiago, Chile Catholic Univ Chile Santiago Chile ept Cell & Mol Biol, Santiago, Chile Univ Paris 06, Dept Cytol, Inst Neurosci, Paris, France Univ Paris 06 Paris France 06, Dept Cytol, Inst Neurosci, Paris, France
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 49, anno: 1999,
pagine: 209 - 214
SICI:
0361-9230(199906)49:3<209:RSNPTT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; REGIONAL DISTRIBUTION; MESSENGER-RNA; ADULT-RAT; IMMUNOREACTIVITY; BRAIN; HYBRIDIZATION; CHOLECYSTOKININ; NEUROPEPTIDES; TERMINALS;
Keywords:
retrograde axonal transport; co-existence; 5-HT; peptides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Araneda, S Univ Lyon 1, Fac Med, INSERM U480, Dept Expt Med, F-69373 Lyon 8, France Univ Lyon 1 Lyon France 8 pt Expt Med, F-69373 Lyon 8, France
Citazione:
S. Araneda et al., "Raphe serotonergic neurons projecting to the olfactory bulb contain galanin or somatostatin but not neurotensin", BRAIN RES B, 49(3), 1999, pp. 209-214

Abstract

Retrograde axonal transport with [H-3]S-HT has been developed as a specific tracing technique to identify serotonergic projections. This method, in combination with immunocytochemistry, offers considerable advantage of specificity and sensitivity to study pathways of multitransmitter-containing neurons. In this work, we studied the presence of galanin, somatostatin, and neurotensin in serotonergic neurons of dorsal and median raphe, which project to the olfactory bulbs. After [H-3]5-HT injections into the rat olfactorybulbs, double galanin-immunoreactive and [H-3]5-HT radiolabelled cells were located in the dorsal, lateral, and ventral region of dorsal raphe, but they were never seen in the median raphe. In the dorsal raphe, galanin-radiolabelled neurons represented 28% of the total number of radiolabelled cells. Double somatostatin-immunoreactive and radiolabelled neurons were locatedin the dorsal and median raphe. In the dorsal raphe, double somatostatin-radiolabelled neurons represented only 11% of the radiolabelled cells and they were mainly located ventral to the aqueduct. In the median raphe, 15% ofradiolabelled cells were also immunopositive for somatostatin. In contrast, neurotensin-immunoreactive cells in the dorsal and median raphe were distributed among [3H]5-HT radiolabelled neurons but they were never radiolabelled. Our results show subpopulations of serotonergic raphe-olfactory bulb projection neurons containing either galanin or somatostatin, but not neurotensin. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 03:40:23