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Titolo:
Central moxonidine on water and NaCl intake
Autore:
Menani, JV; Sato, MA; Haikel, L; Vieira, AA; de Andrade, CAF; da Silva, DCF; Renzi, A; De Luca, LA;
Indirizzi:
UNESP, Fac Odontol, Dept Ciencias Fisiol, BR-14801903 Araraquara, SP, Brazil UNESP Araraquara SP Brazil BR-14801903 BC-14801903 Araraquara, SP, Brazil
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 4, volume: 49, anno: 1999,
pagine: 273 - 279
SICI:
0361-9230(19990701)49:4<273:CMOWAN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED 3-PERCENT NACL; ALPHA-ADRENERGIC AGONISTS; CENTRAL ANGIOTENSIN-II; LATERAL HYPOTHALAMUS; CHOLINERGIC ACTIVATION; ANTIHYPERTENSIVE AGENT; NATRIURETIC RESPONSES; INDUCED DRINKING; 3RD VENTRICLE; SEPTAL AREA;
Keywords:
salt appetite; thirst; angiotensin; water deprivation; alpha(2) adrenergic receptors; imidazoline receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Menani, JV UNESP, Fac Odontol, Dept Ciencias Fisiol, Rua Humaita 1680, BR-14801903 Araraquara, SP, Brazil UNESP Rua Humaita 1680 Araraquara SP BrazilBR-14801903 BCrazil
Citazione:
J.V. Menani et al., "Central moxonidine on water and NaCl intake", BRAIN RES B, 49(4), 1999, pp. 273-279

Abstract

In this study we investigated: (a) the effects of intracerebroventricular (i.c.v.) injections of moxonidine (an alpha(2)-adrenergic and imidazoline receptor agonist) on the ingestion of water and NaCl induced by 24 h of water deprivation; (b) the effects of i.c.v. injection of moxonidine on centralangiotensin II (ANG II)- and carbachol-induced water intake; (c) the effects of the pre-treatment with i.c.v, idazoxan (an alpha(2)-adrenergic and imidazoline receptor antagonist) and RX 821002 (a selective alpha(2)-adrenergic antagonist) on the antidipsogenic action of central moxonidine. Male Holtzman rats had stainless steel cannulas implanted in the lateral cerebral ventricle. Intracerebroventricular injection of moxonidine (5 and 20 nmol/1 mu l) reduced the ingestion of 1.5% NaCl solution (4.1 +/- 1.1 and 2.9 +/- 2.5 ml/2 h, respectively vs. control = 7.4 +/- 2.1 ml/2 h) and water intake(2.0 +/- 0.6 and 0.3 +/- 0.2 ml/h, respectively vs. control = 13.0 +/- 1.4ml/h) induced by water deprivation, Intracerebroventricular moxonidine (5 nmol/1 mu l) also reduced i.c.v. ANG Ii-induced water intake (2.8 +/- 0.9 vs. control = 7.9 +/- 1.7 ml/1 h) and i.c.v. moxonidine (10 and 20 nmol/1 mul) reduced i.c.v. carbachol-induced water intake (4.3 +/- 1.7 and 2.1 +/- 0.9, respectively vs. control = 9.2 +/- 1.0 ml/1 h). The pre-treatment withi.c.v. idazoxan (40 to 320 nmol/1 mu l) abolished the inhibitory effect ofi.c.v, moxonidine on carbachol-induced water intake. Intracerebroventricular idazoxan (320 nmol/1 mu l) partially reduced the inhibitory effect of moxonidine on water deprivation-induced water intake and produced only a tendency to reduce the antidipsogenic effect of moxonidine on ANG Ii-induced water intake. RX 821002 (80 and 160 nmol/1 mu l) completely abolished the antidipsogenic action of moxonidine on ANG Ii-induced water intake. The results show that central injections c: moxonidine strongly inhibit water and NaCl ingestion. They also suggest the involvement of central alpha(2)-adrenergic receptors in the antidipsogenic action of moxonidine. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:31:14