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Titolo:
Postnatal cerebral cortical multipotent progenitors: Regulatory mechanismsand potential role in the development of novel neural regenerative strategies
Autore:
Mehler, MF; Gokhan, S;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Rose F Kennedy Ctr Res Mental Retardat & Dev Disa, Dept Neurol, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 3, volume: 9, anno: 1999,
pagine: 515 - 526
SICI:
1015-6305(199907)9:3<515:PCCMPR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEINS; EPIDERMAL GROWTH-FACTOR; OLIGODENDROCYTE PRECURSOR CELLS; DEVELOPING NERVOUS-SYSTEM; DEVELOPING RAT-BRAIN; PDGF ALPHA-RECEPTOR; ADULT-MOUSE BRAIN; STEM-CELLS; SUBVENTRICULAR ZONE; SPINAL-CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Mehler, MF Yeshiva Univ Albert Einstein Coll Med, Rose F Kennedy Ctr Res Mental Retardat & Dev Disa, Dept Neurol, Room 41,1410 Pelham Pkwy S, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Room 41,1410 Pelham PkwyS Bronx NY USA 10461
Citazione:
M.F. Mehler e S. Gokhan, "Postnatal cerebral cortical multipotent progenitors: Regulatory mechanismsand potential role in the development of novel neural regenerative strategies", BRAIN PATH, 9(3), 1999, pp. 515-526

Abstract

In the developing postnatal cerebral cortex, protracted generation of gliaand neurons occurs and precise matching of local cell types is needed for the functional organization of regional microdomains characteristic of complex CNS tissues. Recent studies have suggested that multipotent progenitorsplay an important role in neural lineage elaboration during neurogenesis and gliogenesis after migration from paramedian generative zones,The presence of a separate reservoir of cerebral cortical multipotent cells under strict local environmental regulation would provide an appropriate mechanism for terminal developmental sculpting and for reconstitution of regional cellular pools after injury. We have isolated distinct pools of EGF- and bFGF-responsive multipotent progenitors from the postnatal mammalian cerebral cortex independent of the subventricular zone. These progenitor populations areunder tight environmental regulation by specific hierarchies of cytokine subclasses that program the progressive elaboration of intermediate lineage-restricted progenitors and differentiated type I and II astrocytes, myelinating oligodendrocytes and neuronal subtypes that express specific neuromodulatory proteins. Neural lineage development from these cortical multipotentprogenitors is a graded developmental process involving sequential induction of specific cytokine receptors, acquisition of factor responsiveness andcomplex lineage interdependence. The cortical multipotent progenitor pathways program the elaboration of neural lineage species with distinct cellular response properties when compared with analogous species derived from subventricular zone progenitors, indicating that the cortical multipotent cells contribute to the establishment of lineage diversity within the developing cortical cortex, In addition, the cortical multipotent cells generate dynamic intermediate progenitor pools that utilize temporally- coded environmental cues to alter neural fate decisions. These cumulative observations suggest that postnatal cerebral cortical multipotent cells represent a novel set of progenitor pathways necessary for normal mammalian cortical maturation, and may have important implications for our understanding of a wide variety of neuropathological conditions and for the development of more effective regenerative strategies to combat these pervasive neurological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:10:23