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Titolo:
The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha 5 beta 1 and alpha v beta 3integrins and by mobilizing sequestered basic fibroblast growth factor
Autore:
Barillari, G; Sgadari, C; Fiorelli, V; Samaniego, F; Colombini, S; Manzari, V; Modesti, A; Nair, BC; Cafaro, A; Sturzl, M; Ensoli, B;
Indirizzi:
Ist Super Sanita, Virol Lab, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 nita, Virol Lab, I-00161 Rome, Italy Univ Rome Tor Vergata, Dept Expt Med, Rome, Italy Univ Rome Tor Vergata Rome Italy or Vergata, Dept Expt Med, Rome, Italy Univ Rome La Sapienza, Dept Allergy & Clin Immunol, I-00185 Rome, Italy Univ Rome La Sapienza Rome Italy I-00185 in Immunol, I-00185 Rome, Italy Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Human Virol, Baltimore, MD 21201 USA Adv BioSci Labs Inc, Kensington, MD 20895 USA Adv BioSci Labs Inc Kensington MD USA 20895 Inc, Kensington, MD 20895 USA GSF, Natl Res Ctr Environm & Hlth, Bavarian Nord Res Inst AS, Martinsried,Germany GSF Martinsried Germany Bavarian Nord Res Inst AS, Martinsried,Germany Tech Univ Munich, Inst Virol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 nst Virol, D-8000 Munich, Germany
Titolo Testata:
BLOOD
fascicolo: 2, volume: 94, anno: 1999,
pagine: 663 - 672
SICI:
0006-4971(19990715)94:2<663:TTPOHI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS FACTOR-ALPHA; KAPOSIS-SARCOMA KS; ENDOTHELIAL-CELLS; T-CELLS; INFLAMMATORY CYTOKINES; SPINDLE CELLS; NUDE-MICE; EXTRACELLULAR MATRIX; FLK-1/KDR RECEPTOR; BASEMENT-MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ensoli, B Ist Super Sanita, Virol Lab, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 taly
Citazione:
G. Barillari et al., "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha 5 beta 1 and alpha v beta 3integrins and by mobilizing sequestered basic fibroblast growth factor", BLOOD, 94(2), 1999, pp. 663-672

Abstract

The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi's sarcoma (KS) development in infected individuals. In this study, we investigated the molecular mechanisms responsible for the angiogenic effects of Tat, The results shown herein indicate that two different Tat domains cooperate to induce these effects by different pathways. The arginine-glycine-aspartic acid (RGD) sequence present at the carboxyterminal of Tat mediates vascular cell migration and invasion by binding tothe alpha 5 beta 1 and alpha v beta 3 integrins, This interaction also provides endothelial cells with the adhesion signal they require to grow in response to mitogens. At the same time, the Tat basic sequence retrieves intoa soluble form extracellular basic fibroblast growth factor (bFGF) bound to heparan sulfate proteoglycans by competing for heparin-binding sites. This soluble bFGF mediates Tat-induced vascular cell growth. These effects resemble those of extracellular matrix proteins, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules. (C) 1999 by The American Society of Hematology.

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Documento generato il 05/07/20 alle ore 22:59:33