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Titolo:
Is surveillance for stage 1 germ cell tumours of the testis appropriate outside a specialist centre?
Autore:
Jones, A; Fergus, JN; Chapman, J; Houghton, L;
Indirizzi:
Northampton Hosp NHS Trust, Northampton, England Northampton Hosp NHS Trust Northampton England st, Northampton, England
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 84, anno: 1999,
pagine: 79 - 84
SICI:
1464-4096(199907)84:1<79:ISFS1G>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL STAGE; TESTICULAR SEMINOMA; ADJUVANT CHEMOTHERAPY; PROGNOSTIC FACTORS; PROSPECTIVE TRIAL; I SEMINOMA; TUMORS; CANCER; MANAGEMENT; RADIOTHERAPY;
Keywords:
teratoma; seminoma surveillance; stage 1; relapse; management;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, A John Radcliffe Hosp, Inst Mol Med, Mol Oncol Grp, Room 418, Oxford OX3 9DS, England John Radcliffe Hosp Room 418 Oxford England OX3 9DS 9DS, England
Citazione:
A. Jones et al., "Is surveillance for stage 1 germ cell tumours of the testis appropriate outside a specialist centre?", BJU INT, 84(1), 1999, pp. 79-84

Abstract

Objective. To assess the results of treatment for stage 1 germ cell tumours of the testis, outside a specialist centre. Patients and methods. From May 1984 until March 1996, 123 patients with stage 1 disease were treated at our institution. Sixty patients with seminomaand 31 with teratoma were treated with orchidectomy only and surveillance;32 patients with stage 1 seminoma elected for orchidectomy and adjuvant radiotherapy. The mean ages were 40, 31 and 35 years, and the median follow-up 52, 47 and 49 months, respectively. Results. There were no disease- or treatment-related deaths. However, 18 (30%) patients with seminoma treated by orchidectomy only relapsed (median time 8 months, range 3-19); 14 of these responded to radiotherapy, three to radiotherapy and chemotherapy for second relapses outside the irradiated fields, and one to chemotherapy initially, for large-volume relapse. Fifteen (48%) patients with teratoma relapsed (median time 3 months, range 1-12); all responded to 4-6 courses of bleomycin/etoposide/cisplatin chemotherapy. One patient had a second relapse and is currently disease-free 3 years after surgical excision of a lung metastasis. Conclusion. These results show that stage 1 testis tumours can be managed successfully in a district general hospital. However, we are concerned about the high relapse rates and are now attempting to identify patients at greater risk of recurrence, to consider adjuvant therapy in this group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:48:25