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Titolo:
Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function
Autore:
Steckler, T; Holsboer, F;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 102, anno: 1999,
pagine: 151 - 163
SICI:
0166-4328(199907)102:1-2<151:ECARIT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; ADRENAL-STEROID RECEPTORS; EXPRESSING ANTISENSE RNA; NUCLEUS-ACCUMBENS; CORTICOSTEROID HORMONES; BASOLATERAL AMYGDALA; EXCITOTOXIC LESIONS; DOPAMINE RELEASE; SPATIAL MEMORY; FOOD-INTAKE;
Keywords:
conditioned exploration; dopamine; food intake; glucocorticoid receptor; reward; transgenic; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Steckler, T Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2-10 Munich Germany D-80804
Citazione:
T. Steckler e F. Holsboer, "Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function", BEH BRA RES, 102(1-2), 1999, pp. 151-163

Abstract

The long-term consequences of impaired glucocorticoid receptor (GR) function on reward-related learning were studied in transgenic mice with impairedGR function in a series of experiments taxing conditioned and unconditioned approach responses to stimuli predictive of food. There was a double-dissociation in that transgenic mice with impaired GR activity showed enhanced conditioned exploration in situations when stimuli predicted reward, while free-feeding food consumption over 24 h was reduced. Previous experiments have shown altered accumbens dopaminergic activity in these animals. In linewith these findings, we observed an enhanced behavioural stimulation of transgenic mice following administration of d-amphetamine (2 mg/kg). This suggests that the increase in preparatory responses in transgenic mice may be mediated via an enhanced accumbens dopaminergic activity, possibly secondary to alterations in other brain systems. (C) 1999 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:32:59