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Titolo:
The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly - Results from the CardiovascularHealth Study
Autore:
Tracy, RP; Arnold, AM; Ettinger, W; Fried, L; Meilahn, E; Savage, P;
Indirizzi:
Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA Univ Vermont, Coll Med, Dept Biochem, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 pt Biochem, Burlington, VT 05405 USA Univ Vermont, Coll Med, Lab Clin Biochem Res, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 iochem Res, Burlington, VT 05405 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Johns Hopkins Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ns Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA v, Dept Epidemiol, Baltimore, MD USA London Sch Hyg & Trop Med, Dept Epidemiol & Populat Sci, London WC1, England London Sch Hyg & Trop Med London England WC1 at Sci, London WC1, England NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 19, anno: 1999,
pagine: 1776 - 1783
SICI:
1079-5642(199907)19:7<1776:TROFAF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; CORONARY-ARTERY DISEASE; COAGULATION-FACTOR-VII; PLASMA FACTOR-VII; MYOCARDIAL-INFARCTION; RISK FACTOR; PLASMINOGEN-ACTIVATOR; HEMOSTATIC FUNCTION; ATHEROSCLEROSIS; MEN;
Keywords:
atherosclerosis; cardiovascular diseases; fibrinogen; risk factors; thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Tracy, RP CHS Coordinating Ctr, Century Sq,Suite 2025,1501 4th Ave, Seattle, WA 98101 USA CHS Coordinating Ctr Century Sq,Suite 2025,1501 4th Ave Seattle WA USA 98101
Citazione:
R.P. Tracy et al., "The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly - Results from the CardiovascularHealth Study", ART THROM V, 19(7), 1999, pp. 1776-1783

Abstract

Little is known about the prospective associations of fibrinogen, factor VII, or factor VIII with cardiovascular disease (CVD) and mortality in the elderly. At baseline in the Cardiovascular Health Study (5888 white and African American men and women; aged greater than or equal to 65 years), we measured fibrinogen, factor VIII, and factor VII. We used sex-stratified stepwise Cox survival analysis to determine relative risks (RRs) for CVD events and all-cause mortality (up to 5 years of follow-up), both unadjusted and adjusted for CVD risk factors and subclinical CVD. After adjustment, comparing the fifth quintile to the first, fibrinogen was significantly associatedin men with coronary heart disease events (RR=2.1) and stroke or transientischemic attack (RR=1.3), and also with mortality within 2.5 years of follow-up (RR=5.8) and later (RR=1.7). Factor VIII was significantly associatedin men with coronary heart disease events (RR=1.5) and mortality (RR=1.8),and in women with stroke/transient ischemic attack (RR=1.4). For both factors, values were higher in those who died, whether causes were CVD-related or non-CVD-related, but highest in CVD death. Factor VII exhibited associations with incident angina (RR=1.44) in men and with death in women (RR, middle quintile compared with first=0.66). However, in general, factor VII wasnot consistently associated with CVD events in this population. We conclude that, if confirmed in other studies, the measurement of fibrinogen and/orfactor VIII may help identify older individuals at higher risk for CVD events and mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:05:57