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Titolo:
Temporal trends in the use of anticoagulants among older adults with atrial fibrillation
Autore:
Smith, NL; Psaty, BM; Furberg, CD; White, R; Lima, JAC; Newman, AB; Manolio, TA;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA USA Univ Washington Seattle WA USA shington, Dept Epidemiol, Seattle, WA USA Univ Washington, Hlth Serv, Seattle, WA USA Univ Washington Seattle WA USA iv Washington, Hlth Serv, Seattle, WA USA Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA bl Hlth Sci, Winston Salem, NC USA Univ Calif Davis, Div Gen Med, Davis, CA 95616 USA Univ Calif Davis DavisCA USA 95616 vis, Div Gen Med, Davis, CA 95616 USA Johns Hopkins Univ, Div Cardiol, Hagerstown, MD USA Johns Hopkins Univ Hagerstown MD USA iv, Div Cardiol, Hagerstown, MD USA Univ Pittsburgh, Dept Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ttsburgh, Dept Med, Pittsburgh, PA USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 14, volume: 159, anno: 1999,
pagine: 1574 - 1578
SICI:
0003-9926(19990726)159:14<1574:TTITUO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; WARFARIN USE; CARDIOVASCULAR HEALTH; NATIONAL PATTERNS; PREVALENCE; ASPIRIN; PREVENTION; REGISTRY; FAILURE; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, NL Cardiovasc Hlth Res Unit, 1730 Minor Ave,Suite 1360, Seattle, WA98101 USA Cardiovasc Hlth Res Unit 1730 Minor Ave,Suite 1360 Seattle WA USA 98101
Citazione:
N.L. Smith et al., "Temporal trends in the use of anticoagulants among older adults with atrial fibrillation", ARCH IN MED, 159(14), 1999, pp. 1574-1578

Abstract

Background: Several recent randomized clinical trials have demonstrated that warfarin sodium treatment, and to a lesser extent aspirin, reduces risk of stroke and death compared with placebo in persons with atrial fibrillation. Insufficient documentation exists on the extent to which the use of these therapies following trial publications has continued to increase in the elderly with atrial fibrillation. Methods: We used data from the Cardiovascular Health Study, a study of 5888 community-dwelling adults aged 65 years or older, to determine the prevalence of warfarin and aspirin use in persons with electrocardiogram-identified atrial fibrillation. Electrocardiogram examinations were conducted at baseline from 1989 through 1990, and at 6 subsequent annual examinations through 1995-1996. Medication data were collected by inventory methods at each examination. Temporal change in use of anticoagulants was analyzed by comparing percentage use in 1990 to use in each year through 1996. Results: The use of warfarin increased 4-fold from 13% in 1990 to 50% in 1996 among participants with prevalent atrial fibrillation (P < .001). Dailyuse of aspirin did not increase over time. Participants younger than 80 years were 4 times more likely to use warfarin in 1996 (P < .001) than those 80 years and older. Use of aspirin did not vary significantly with age. Conclusions: Warfarin use in community-dwelling elderly persons with electrocardiogram-documented atrial fibrillation increased steadily following the first publication of its treatment benefit, reaching 50% by 1996. In contrast, use of aspirin was unchanged during this same period. Continued efforts to promote appropriate antil coagulation therapy to physicians and theirpatients may still be needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:11:14