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Titolo:
Engineering aspects of beta-lactam biosynthesis
Autore:
van den Berg, MA; Bovenberg, RAL; de Laat, WTAM; van Velzen, AG;
Indirizzi:
Gist Brocades, Ind Pharmaceut Prod Div, NL-2600 MA Delft, Netherlands GistBrocades Delft Netherlands NL-2600 MA NL-2600 MA Delft, Netherlands
Titolo Testata:
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
fascicolo: 1-2, volume: 75, anno: 1999,
pagine: 155 - 161
SICI:
0003-6072(199901/02)75:1-2<155:EAOBB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENICILLIUM-CHRYSOGENUM; ACREMONIUM-CHRYSOGENUM; ISOPENICILLIN N; RING EXPANSION; GENE; EXPRESSION; DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE; INVOLVEMENT; SYNTHETASE; PRODUCTS;
Keywords:
biosynthesis; engineering; beta-lactams; metabolic pathway engineering; strain improvement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bovenberg, RAL Gist Brocades, Ind Pharmaceut Prod Div, Wateringseweg 1,Postbus 1, NL-2600MA Delft, Netherlands Gist Brocades Wateringseweg 1,Postbus 1 Delft Netherlands NL-2600 MA
Citazione:
M.A. van den Berg et al., "Engineering aspects of beta-lactam biosynthesis", ANTON LEEUW, 75(1-2), 1999, pp. 155-161

Abstract

The adaptation of an existing industrial production line to boost production capacity (a hardware analogue of strain improvement) or to enable the production of a derivative of the original product is used as an example to explore the similarities between process design and engineering and metabolic pathway engineering. In the two fields the same principles appear to apply: for most process engineering solutions metabolic pathway engineering analogues can be found. Analogues are illustrated by reference to literature (e.g. overproduction of amino acid precursors at the 'bottom' of the pathway, relocalisation of proteins and overexpression of genes from the secondarymetabolism). Some possible future applications are defined (e.g. supervisory manipulations as regulation by gene transcription factors).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:59:07