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Titolo:
Effect of schistosomiasis and hepatitis on liver disease
Autore:
Halim, AB; Garry, RF; Dash, S; Gerber, MA;
Indirizzi:
Tulane Univ, Med Ctr, Dept Pathol & Lab Med, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 & Lab Med, New Orleans, LA 70112 USA Al Azhar Univ, Fac Pharm, Dept Biochem, Cairo, Egypt Al Azhar Univ CairoEgypt r Univ, Fac Pharm, Dept Biochem, Cairo, Egypt Tulane Univ, Med Ctr, Dept Microbiol, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 Microbiol, New Orleans, LA 70112 USA
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 6, volume: 60, anno: 1999,
pagine: 915 - 920
SICI:
0002-9637(199906)60:6<915:EOSAHO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
C VIRUS GENOTYPES; NON-B-HEPATITIS; POLYMERASE CHAIN-REACTION; EGYPTIAN BLOOD-DONORS; A-E HEPATITIS; PHYLOGENETIC ANALYSIS; HIGH SEROPREVALENCE; VIRAL-HEPATITIS; UNITED-STATES; GBV-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Dash, S Tulane Univ, Med Ctr, Dept Pathol & Lab Med, 1430 Tulane Ave, New Orleans,LA 70112 USA Tulane Univ 1430 Tulane Ave New Orleans LA USA 70112 ,LA 70112 USA
Citazione:
A.B. Halim et al., "Effect of schistosomiasis and hepatitis on liver disease", AM J TROP M, 60(6), 1999, pp. 915-920

Abstract

Infection with hepatitis C virus (HCV) has become the most important public health problem in Egypt. In Egypt, viral hepatitis along with infection with Schistosoma mansoni is the major cause of chronic liver disease and liver cirrhosis. Although HCV infection is highly prevalent in Egypt, very little information is available on the distribution of the different genotypesof HCV. Our aims in this study were first to determine the prevalence of viral and parasite infections in patients with chronic liver disease and then to assess the distribution of HCV genotypes in these patients. In the present study, 151 individuals (50 with chronic liver disease, 51 with chronicdiseases of organs other than the liver, and 50 apparently healthy persons) were investigated. The last 2 groups served as control groups. These individuals were subjected to routine liver function tests and detection of serum antibodies to bilharziasis, hepatitis B surface antigen (HBsAg), and HCV. Furthermore, the presence of hepatitis G virus (HGV) and HCV in the serumsamples were tested for by a reverse transcription polymerase chain reaction (RT-PCR). Prevalence of different genotypes of HCV in patients positive for HCV were determined by RT-PCR using type-specific primers. Results of the study revealed that 84, 74, 12, and 20% of patients with chronic liver disease were positive for Schistosoma mansoni, HCV, HBsAg, and HGV, respectively, as compared to 51, 43.1, 2, and 4% of patients with other chronic diseases and 22, 6, 0, and 0% of apparently healthy individuals. One hundred percent of patients with chronic liver disease, 72.5% of those with other diseases, and 26% of normal controls were shown to have at least one of the studied infectious agents. Two or more of the agents were highly coincident in patients with chronic liver disease. In Egypt, HCV genotype 4a is highlyprevalent, where it contributed 85% of the tested samples in comparison to10, 2.5, and 2.5% for subtypes 1b, 2a, and 3a, respectively. In conclusion, these results suggest that in Egypt, HCV along with schistosomal parasiteinfection is the major risk factor for chronic liver disease. In most Egyptian patients, HCV genotype 4 is highly prevalent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:17:55