Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of FIO2 on hemodynamic responses and O-2 transport during RSR13-induced reduction in P-50
Autore:
Eichelbronner, O; Sielenkamper, A; DAlmeida, M; Ellis, CG; Sibbald, WJ; Chin-Yee, IH;
Indirizzi:
Univ Western Ontario, AC Burton Vasc Biol Lab, London, ON N6A 4G5, Canada Univ Western Ontario London ON Canada N6A 4G5 London, ON N6A 4G5, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 46, anno: 1999,
pagine: H290 - H298
SICI:
0363-6135(199907)46:1<H290:EOFOHR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLOSTERIC MODIFIERS; DISSOCIATION CURVE; OXYGEN-AFFINITY; HEMOGLOBIN; MUSCLE; VASODILATION; DELIVERY; SATURATION; INCREASES; DECREASES;
Keywords:
oxygen affinity; oxygen transport; oxygen tension at half-saturation of hemoglobin; tissue oxygenation availability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Chin-Yee, IH London Hlth Sci Ctr, Westminster Campus,800 Commissioners Rd E, London, ONN6A 4G5, Canada London Hlth Sci Ctr Westminster Campus,800 Commissioners Rd E London ON Canada N6A 4G5
Citazione:
O. Eichelbronner et al., "Effects of FIO2 on hemodynamic responses and O-2 transport during RSR13-induced reduction in P-50", AM J P-HEAR, 46(1), 1999, pp. H290-H298

Abstract

Reduced Hb-O-2 affinity facilitates O-2 release to tissue but may impair pulmonary O-2 uptake, affecting cardiac output and systemic vascular resistance (SVR). We studied the effects of shifting the O-2-dissociation curve (ODC) to the right with a continuous infusion of RSR13, an allosteric modifier of Hb, and of different inspired O-2 fractions (FIO2) On arterial O-2 saturations (Sa(O2)) in Rb and on hemodynamics in nonanesthetized rats. At an FIO2 of 0.21, Sa(O2) fell during RSR13 from 95 to 81%. Elevation of FIO2 to0.30 returned Sa(O2) to baseline in the RSR13 group. The decrease in mean arterial pressure (MAP) was significantly greater in the control than in the RSR1S group at 30% O-2. Cardiac index (CI) increased only during RSR13 at21% O-2 and returned to baseline at 30% O-2 In contrast, SVR decreased after RSR13 was infused at 21% O-2 but returned to baseline at 30% O-2, whereas controls showed the opposite, a sustained SVR. In the follow-up period, when 21 O-2% was reestablished and mild anemia was present, MAP and SVR fellsignificantly more in controls, whereas CI only increased in controls. Lactate was significantly lower in the RSR13 than in the control group during RSR13 and the follow-up period. These results demonstrate that 1) continuous infusion of RSR13 produces a constant shift in the O-2 tension at which Hb is 50% saturated (P-50), 2) FIO2 Of 0.30 compensates for the effects of increased P-50 on pulmonary O-2 loading, and 3) right-shifted ODC combined with supplemental O-2 may improve tissue O-2 availability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:14:55