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Titolo:
Correlation between cytochrome P-450CYP2D6 CYP2D6) genotype and phenotype
Autore:
Chen, SQ; Wedlund, PJ;
Indirizzi:
Zhejiang Univ, Coll Med, Dept Biochem, Hangzhou 310006, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310006 ou 310006, Peoples R China Univ Kentucky, Coll Pharm, Dept Pharmacol & Expt Therapeut, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 t Therapeut, Lexington, KY 40536 USA
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 7, volume: 20, anno: 1999,
pagine: 585 - 588
SICI:
0253-9756(199907)20:7<585:CBCPCG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZERS; DEBRISOQUINE; GENE; SPARTEINE; ALLELE;
Keywords:
cytochrome P-450CYP2D6; genotype; phenotype; alleles; polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, SQ Zhejiang Univ, Coll Med, Dept Biochem, Hangzhou 310006, Peoples RChina Zhejiang Univ Hangzhou Peoples R China 310006 , Peoples R China
Citazione:
S.Q. Chen e P.J. Wedlund, "Correlation between cytochrome P-450CYP2D6 CYP2D6) genotype and phenotype", ACT PHAR SI, 20(7), 1999, pp. 585-588

Abstract

ATM: To study the correlation between CYP2D6 genotype and its phenotype. METHODS: CYP2D6 genotyping was made by detecting CYP2D6 *3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure. RESULTS: The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at least one wildtype CYP2D6 gene and the genotypes were *1/*1, *1/*3, and *1/*4. Poor metabolizers were found to be homozygous mutants of CYP2D6 gene and the genotypes were *3/*4, *4/*4, *3/*6, *4/*7, *4/*6, and *6/*6. CONCLUSION: Genotype could be used to screen variations of CYP2D6 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:29:02