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Titolo:
Analysis of factors influencing long-term survival after surgical resection for oesophageal squamous cell carcinoma
Autore:
Kolh, P; Honore, P; Gielen, JL; Degauque, C; Azzam, C; Legrand, M; Jacquet, N;
Indirizzi:
CHU Sart Tilman, Dept Surg, B-4000 Liege, Belgium CHU Sart Tilman Liege Belgium B-4000 n, Dept Surg, B-4000 Liege, Belgium
Titolo Testata:
ACTA CHIRURGICA BELGICA
fascicolo: 3, volume: 99, anno: 1999,
pagine: 113 - 118
SICI:
0001-5458(199906)99:3<113:AOFILS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTORS; ESOPHAGEAL-CARCINOMA; ESOPHAGOGASTRIC JUNCTION; DNA-PLOIDY; CANCER; ADENOCARCINOMA; SURGERY; CHEMOTHERAPY; THORACOTOMY; RECURRENCE;
Keywords:
oesophagus, cancer; chemotherapy; radiation; combined modality therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kolh, P Univ Hosp Liege, Dept Cardiothorac Surg, B35, B-4000 Liege, Belgium Univ Hosp Liege B35 Liege Belgium B-4000 5, B-4000 Liege, Belgium
Citazione:
P. Kolh et al., "Analysis of factors influencing long-term survival after surgical resection for oesophageal squamous cell carcinoma", ACT CHIR B, 99(3), 1999, pp. 113-118

Abstract

Objective : We evaluated prognostic factors in 34 patients discharged fromhospital after surgical resection for oesophageal squamous cell carcinoma. Material and Methods: There were 22 males and 12 females; mean age was 59.3 years (range 42-77 years). Preoperative neoadjuvant treatment consisted in chemotherapy alone in three patients and in combined radiochemotherapy in14. Digestive continuity was restored with a gastric transplant in 26 patients and a colonic graft in 8. Surgery was curative in 28 patients and palliative in 6. There were three stage I, 14 stage II, 13 stage III, and 4 stage IV diseases. In 19 patients the lymph nodes were invaded. The tumour waswell differentiated in 17 patients, moderately in 9, and poorly in 8. Results: Follow-up ranged from 2 to 100 months. Overall median postoperative survival was 21 months. By univariate analysis, factors influencing survival were curative surgery (p = 0.04), stage (p = 0.006), and nodal involvement (p = 0.0003). Nodal involvement was an independent prognostic factor by multivariate analysis (p = 0.0002). Patient age and sex, perioperative transfusion, digestive transplant, tumour local extension, grade of differentiation, and distant metastasis did not influence survival. Also, we did notobserve any significant benefit of preoperative or postoperative chemotherapy or radiochemotherapy. Conclusions: Nodal involvement was the most important prognostic factor influencing survival. Therefore, an earlier diagnosis of oesophageal cancer in a less advanced stage is important to improve survival rates. Our study could not confirm the benefit of neoadjuvant therapy in terms of late survival.

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Documento generato il 06/04/20 alle ore 21:41:45