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Titolo:
Regulation of apoptosis in the prostate gland by androgenic steroids
Autore:
Buttyan, R; Shabsigh, A; Perlman, H; Colombel, M;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Urol, New York, NY 10032 USA ColumbiaUniv Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA CHU Lyon 1, Hop Edouard Herriot, Serv Urol & Chirurg Transplantat, F-69437Lyon, France CHU Lyon 1 Lyon France F-69437 Chirurg Transplantat, F-69437Lyon, France
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 10, anno: 1999,
pagine: 47 - 54
SICI:
1043-2760(199903)10:2<47:ROAITP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL PROSTATE; PROGRAMMED CELL-DEATH; CASTRATION-INDUCED INVOLUTION; REGIONAL VARIATION; DNA FRAGMENTATION; EPITHELIAL-CELLS; GENE-EXPRESSION; DUCTAL SYSTEM; BLOOD-FLOW; BCL-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Buttyan, R Columbia Univ Coll Phys & Surg, Dept Urol, Atchley Pavil,11th Floor,161 FtWashington Blvd, New York, NY 10032 USA Columbia Univ Coll Phys & Surg Atchley Pavil,11th Floor,161 Ft Washington Blvd New York NY USA 10032
Citazione:
R. Buttyan et al., "Regulation of apoptosis in the prostate gland by androgenic steroids", TRENDS ENDO, 10(2), 1999, pp. 47-54

Abstract

The prostate gland requires androgenic steroids for its appropriate embryological formation and postpubertal growth and, once at adult size, remains dependent on a continuous supply of androgens for its vitality and function. A reduction of the levels of circulating androgens will rapidly induce apoptosis of the cells of the prostate, leading to extensive glandular regression. Studies of rodent models of prostate response to castration have shown that there are some remarkable changes in the gene activity of prostate epithelial cells leading tip to apoptosis. There is now evidence for a critical cell signaling pathway, regulated by c-fos expression, necessary for castration-induced apoptosis, as well as evidence that this signaling initiates an abrupt and transient alteration in the synthesis of fas antigen, p53,bax and bcl-2 proteins in the androgen receptor-expressing prostate epithelial cells, the cellular compartment that appears to be the most affected by castration. However, more recent studies suggest that these castration-induced effects on the prostate epithelial cells might be, at least in part, an indirect response to a critical reduction in blood flow to the prostate gland that precedes the onset of epithelial cell apoptosis. The castration effects on blood flow to the prostate gland seem to be related to vascular degeneration associated with apoptosis of a subset of prostate endothelial cells.

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Documento generato il 02/07/20 alle ore 18:57:41