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Titolo:
Acute and chronic administration of the selective sigma(1) receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
Autore:
Minabe, Y; Matsuno, K; Ashby, CR;
Indirizzi:
St Johns Univ, Pharmaceut Hlth Sci Dept, Jamaica, NY 11439 USA St Johns Univ Jamaica NY USA 11439 t Hlth Sci Dept, Jamaica, NY 11439 USA Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Div Cort Funct Disorders, Kodaira, Tokyo, Japan Natl Ctr Neurol & Psychiat Kodaira Tokyo Japan rs, Kodaira, Tokyo, Japan Santen Pharmaceut Co Ltd, Cent Res Labs, New Drug Res, Osaka 533, Japan Santen Pharmaceut Co Ltd Osaka Japan 533 New Drug Res, Osaka 533, Japan
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 33, anno: 1999,
pagine: 129 - 140
SICI:
0887-4476(199908)33:2<129:AACAOT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; METHYL-D-ASPARTATE; POTENTIAL ANTIPSYCHOTIC DRUG; CENTRAL NERVOUS-SYSTEM; PCP BINDING-SITES; PREFRONTAL CORTEX; N-ALLYLNORMETAZOCINE; OPIATE RECEPTORS; HIGH-AFFINITY; AUTORADIOGRAPHIC VISUALIZATION;
Keywords:
sigma receptors; dopamine; in vivo electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, CR St Johns Univ, Pharmaceut Hlth Sci Dept, Jamaica, NY 11439 USA St Johns Univ Jamaica NY USA 11439 Dept, Jamaica, NY 11439 USA
Citazione:
Y. Minabe et al., "Acute and chronic administration of the selective sigma(1) receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study", SYNAPSE, 33(2), 1999, pp. 129-140

Abstract

In this study, we examined the effect of the acute and repeated administration of the selective sigma (sigma)(1) receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on the numberand firing pattern of spontaneously active dopamine (DA) neurons in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized, male Sprague-Dawley rats. This was accomplished using the technique of in vivo extracellular single unit recording. The intravenous administration of SA4503 (0.01-1.28 mg/kg) did not significantly alter the firing rate or pattern of spontaneously active DA neurons in either the SNC or VTA. A single injection of either 0.1 or 0.3 mg/kg i.p, of SA4503 did not alter thenumber of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of 1 mg/kg i.p. of SA4503 produced a significant decrease and increase in the number of spontaneously active SNC and VTA DA neurons, respectively. Overall, the firing pattern parameters of spontaneously active SNC DA neurons were altered more significantly than those of spontaneously active VTA DA neurons following the acute administration of SA4503. The repeated administration (one injection per day for 21 days) of 0.3 and 1 mg/kg i.p. of SA4503 produced a significant increase in the number of spontaneously active VTA DA neurons. In addition, the repeated administration of SA4503produced a greater alteration of the firing pattern of spontaneously active VTA compared to SNC DA neurons. Our results suggest that the administration of SA4503 significantly alters the activity of spontaneously active midbrain DA neurons, particularly those in the VTA following repeated administration. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:06:03