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Titolo:
Neurotensin studies in alcohol naive, preferring and non-preferring rats
Autore:
Ehlers, CL; Somes, C; Li, TK; Lumeng, L; Kinkead, B; Owens, MJ; Nemeroff, CB;
Indirizzi:
Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Res Inst La Jolla CA USA 92037 opharmacol, La Jolla, CA 92037 USA Indiana Univ, Sch Med, Indianapolis, IN USA Indiana Univ Indianapolis IN USA ana Univ, Sch Med, Indianapolis, IN USA VAMC, Indianapolis, IN USA VAMC Indianapolis IN USAVAMC, Indianapolis, IN USA Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 93, anno: 1999,
pagine: 227 - 236
SICI:
0306-4522(1999)93:1<227:NSIANP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; CENTRAL-NERVOUS-SYSTEM; QUANTITATIVE TRAIT LOCI; ADMINISTERED NEUROTENSIN; STIMULUS PARAMETERS; NONPREFERRING RATS; BRAIN NEUROTENSIN; SELF-INFUSION; BINDING-SITES; ORAL ETHANOL;
Keywords:
alcohol-preferring rats; electroencephalogram; event-related potentials; P300; spectral analysis; alcoholism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Ehlers, CL Scripps Res Inst, Dept Neuropharmacol, 10550 N Torrey Pines Rd,La Jolla, CA 92037 USA Scripps Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
C.L. Ehlers et al., "Neurotensin studies in alcohol naive, preferring and non-preferring rats", NEUROSCIENC, 93(1), 1999, pp. 227-236

Abstract

Neurotensin is a tridecapeptide, present in the central nervous system andthe gastrointestinal tract in man and animals. Previous studies in mice selectively bred for differences in hypnotic sensitivity to ethanol have provided data to suggest that neurotensinergic systems may mediate differences in ethanol's actions in these animals. The present study sought to determine if brain neurotensin levels differed between two lines of rats which havebeen selectively bred for alcohol preferring or non-preferring behaviors. In addition, electroencephalographic and event-related potential responses to intracerebroventricular saline and neurotensin (10 or 30 mu g) were evaluated between the rat lines. Similar to human subjects at high genetic riskfor alcoholism, preferring rats were found to have more electroencephalographic fast frequency activity and lowered amplitude of the P3 component of the event-related potential in cortical sites under the saline condition. Overall, electrophysiological response to neurotensin, in the two rats lines, was substantially similar to what has been reported previously in outbredWistar rats, and consisted of dose-related decreases in overall electroencephalographic spectral power concomitant with increases in amplitude and decreases in the latency of the N1 component of the event-related potential. However, differences in neurotensin responses between the preferring and nonpreferring rat lines were also found. The differences in electroencephalographic high-frequency activity and in P3 amplitude seen between the rat lines under control conditions were eliminated by administration of neurotensin. In addition, preferring rats appeared to be more sensitive to neurotensin-induced increases in N1 amplitude. Brain neurotensin concentrations were also found to differ between the lines. Significantly lower concentrations of neurotensin were found in the frontal cortex of preferring rats when compared to non-preferring rats or outbred Wistars. Taken together, these studies suggest that differences in the regulation of neurotensin neurons may contribute to the expression of behavioral preference for ethanol consumption in selective rat lines. Additionally, drugs targeting the neurotensinergic system may plausibly be of utility in the treatment of alcoholism. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 27/01/20 alle ore 16:54:33