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Titolo:
Functional high- and low affinity agonist binding sites at native dorsal horn AMPA receptors
Autore:
Rybalchenko, V; Schlichter, R;
Indirizzi:
Univ Strasbourg 1, CNRS, UMR 7519, Lab Neurophysiol Cellulaire & Integree,F-67084 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67084 e,F-67084 Strasbourg, France
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 10, anno: 1999,
pagine: 1803 - 1806
SICI:
0959-4965(19990603)10:8<1803:FHALAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; NEURONS; EXPRESSION; SYNAPSES; MEMBRANE; SUBUNITS; CELL;
Keywords:
dorsal horn; excitatory postsynaptic currents (EPSC); glutamate receptors; kainic acid; nociception; pain; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Schlichter, R Univ Strasbourg 1, CNRS, UMR 7519, Lab Neurophysiol Cellulaire & Integree,21 Rue Rene Descartes, F-67084 Strasbourg, France Univ Strasbourg 1 21 Rue Rene Descartes Strasbourg France F-67084
Citazione:
V. Rybalchenko e R. Schlichter, "Functional high- and low affinity agonist binding sites at native dorsal horn AMPA receptors", NEUROREPORT, 10(8), 1999, pp. 1803-1806

Abstract

TRANSMISSION and dorsal horn (DH) of the spinal cord involves activation of AMPA-type glutamate receptors (AMPARs). We have studied the properties ofnative AMPARs in freshly dissociated laminae I-II neurones from postnatal rats using a modified form of the concentration-clamp technique for fast agonist application. Analysis of kainic acid dose-response curves showed the existence of two types of functional agonist binding sites governing AMPAR activation. These sites differ by their affinity for the agonist. Dependingon the neurotransmitter concentration reached in the synaptic cleft, the relative contribution of high affinity and low affinity sites might play an important role in the shaping of AMPAR-mediated postsynaptic currents. NeuroReport 10:1803-1806 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:25:39