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Titolo:
Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome
Autore:
Nakaya, T; Takahashi, H; Nakamura, Y; Kuratsune, H; Kitani, T; Machii, T; Yamanishi, K; Ikuta, K;
Indirizzi:
Osaka Univ, Dept Virol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ial Dis, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Microbiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 crobiol, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Hematol & Oncol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 & Oncol, Suita, Osaka 5650871, Japan Hokkaido Univ, Inst Immunol Sci, Sect Serol, Kita Ku, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan
Titolo Testata:
MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 7, volume: 43, anno: 1999,
pagine: 679 - 689
SICI:
0385-5600(1999)43:7<679:BDVIIT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; EPSTEIN-BARR VIRUS; SEQUENCE CONSERVATION; PSYCHIATRIC-PATIENTS; JAPANESE PATIENTS; RNA; PREVALENCE; ANTIBODIES; DISORDERS; DONORS;
Keywords:
BDV; CFS; family cluster; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nakaya, T Osaka Univ, Dept Virol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 uita, Osaka 5650871, Japan
Citazione:
T. Nakaya et al., "Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome", MICROB IMMU, 43(7), 1999, pp. 679-689

Abstract

A high rate of Borna disease virus (BDV) infection has been demonstrated in patients with chronic fatigue syndrome (CFS). Herein, we focused on BDV infection in two family clusters of patients with CFS: a father, mother, twosons and one daughter (family #1); and a father, mother, two daughters andone son (family #2). All members, except for the elder son in family #1 and the father and son in family #2, were diagnosed with CFS, The results supported that all the family members with CFS were infected with BDV, as evidenced by the presence of antibodies to viral p40, p24 and/or gp18 and BDV p24 RNA in peripheral blood mononuclear cells. The healthy members, except for the father of family #2 who was positive for antibody to p24, were all negative by both assays. Follow-up studies in family #1 continued to reveal BDV antibodies and BDV RNA, except in the mother, who lost the RNA upon slight recovery from the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:32:22