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Titolo:
Nociceptin orphanin FQ: Effects on thermoregulation in rats
Autore:
Yakimova, KS; Pierau, FK;
Indirizzi:
Fac Med, Dept Pharmacol, Sofia 1431, Bulgaria Fac Med Sofia Bulgaria 1431 ac Med, Dept Pharmacol, Sofia 1431, Bulgaria Max Planck Inst Phsyiol & Klin Forsch, WG Kerckhoff Inst, Bad Nauheim, Germany Max Planck Inst Phsyiol & Klin Forsch Bad Nauheim Germany heim, Germany
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 21, anno: 1999,
pagine: 345 - 352
SICI:
0379-0355(199906)21:5<345:NOFEOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE-SENSITIVE NEURONS; PROTEIN-COUPLED RECEPTOR; OPIOID RECEPTOR; HYPOTHALAMIC NEURONS; MOLECULAR-CLONING; ORL1 RECEPTOR; AGONISTS; FAMILY; ANTAGONIST; MEMBER;
Keywords:
nociceptin orphanin FQ; hypothalamic neurons; temperature sensitivity; hypothermia; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yakimova, KS Fac Med, Dept Pharmacol, Zdrave 2 Str, Sofia 1431, Bulgaria Fac Med Zdrave 2 Str Sofia Bulgaria 1431 ofia 1431, Bulgaria
Citazione:
K.S. Yakimova e F.K. Pierau, "Nociceptin orphanin FQ: Effects on thermoregulation in rats", METH FIND E, 21(5), 1999, pp. 345-352

Abstract

Nociceptin/orphanin FQ is a 17 amino acid peptide which acts as a potent endogenous agonist of the opioid receptor-like 1 (ORL1) receptor ORL1 receptor is a G protein-coupled unique member of the cloned opioid receptor family. We have investigated the effects of nociceptin (1, 10 and 100 nM) on thetemperature sensitivity of neurons from the preoptic area of the anterior hypothalamus (PO/AH) in rat brain slices. The body temperature of male Wistar rats was measured after intrahypothalamic application of nociceptin (1 nM) via cannulas in the PO/AH. Low dose nociceptin (1 nM) significantly increased (p < 0.05) temperature sensitivity (TC) of warm-sensitive PO/AH neurons, while the high concentration (100 nM) decreased TC in both warm-sensitive and temperature-insensitive neurons. Similar agonistic activity was obtained after addition of [Phe(1)psi (CH2-NH) Gly(2)]-nociceptin-(1-13)-NH2 (1, 10 and 100 nM), recently proposed to be a selective antagonist of the nociceptin receptor: Neither antagonism nor additive synergism were observed when nociceptin and [Phe(1)psi(CH2-NH) Gly(2)]-nociceptin-(1-13)-NH2 were applied simultaneously in equimolar concentrations. The selective opioid OP3 receptor antagonist CTOP, the selective opioid OP2 receptor antagonist nor-binaltorphimine and selective opioid OP1 receptor antagonist naltrindol hadno influence on the effects of nociceptin on temperature sensitivity in PO/AH neurons. In vivo experiments showed that nociceptin (1 nM; 1 mu l/rat) significantly decreased body temperature (p < 0.05) between 30 and 60 min after intrahypothalamic application. These data are in agreement with the hypothesis that the specific action of endogenous substances on body temperature appears to be closely related to a specific change in the temperature sensitivity of warm-sensitive PO/AH neurons. (C)1999 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:15:13