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Titolo:
The incorporation of fatty acids of different chain length into liver and biliary lipids in the perfused rat liver
Autore:
Rubin, M; Pakula, R; Gilat, T; Tietz, A;
Indirizzi:
Beilinson Med Ctr, Dept Surg B, IL-49100 Petah Tiqwa, Israel Beilinson MedCtr Petah Tiqwa Israel IL-49100 -49100 Petah Tiqwa, Israel Felsenstein Med Res Ctr, IL-49100 Petah Tiqwa, Israel Felsenstein Med Res Ctr Petah Tiqwa Israel IL-49100 Petah Tiqwa, Israel Tel Aviv Univ, Minerva Ctr Cholesterol Gallstones & Lipid Metab, Sackler Fac Med, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 ac Med, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr, Dept Gastroenterol, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr Tel Aviv Israel IL-64239 rol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Dept Neurobiochem, Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel Univ, Dept Neurobiochem, Tel Aviv, Israel
Titolo Testata:
LIPIDS
fascicolo: 6, volume: 34, anno: 1999,
pagine: 571 - 578
SICI:
0024-4201(199906)34:6<571:TIOFAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL GALLSTONE FORMATION; DIETARY PHOSPHOLIPIDS; PARENTERAL-NUTRITION; GALLBLADDER BILE; SECRETION; N-3; SATURATION; SOLUBILITY; NUCLEATION; TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, M Beilinson Med Ctr, Dept Surg B, IL-49100 Petah Tiqwa, Israel Beilinson Med Ctr Petah Tiqwa Israel IL-49100 tah Tiqwa, Israel
Citazione:
M. Rubin et al., "The incorporation of fatty acids of different chain length into liver and biliary lipids in the perfused rat liver", LIPIDS, 34(6), 1999, pp. 571-578

Abstract

In an attempt to correlate the incorporation of fatty acids (FA) of different chain length into liver and biliary lipids, isolated rat livers were perfused for 2 h with Krebs-Ringer bicarbonate containing 1% albumin and 10 mu mol of [1-C-14]-labeled FA: C-2, C-8, C-10, C-12, C-16; and C-18:1. One to 1.36 mu mol of medium-chain fatty acids (MCFA, C-8, C-10, and C-12) and 6.6 mu mol of long-chain FA (LCFA) were incorporated into liver lipids, 40% of the latter into phosphatidylcholine (PC). C-14-acetate (13 nmol) was incorporated into biliary cholesterol; C-14-MCFA contributed only 3.2-5 nmol; LCFA did not lead to newly synthesized cholesterol. Newly synthesized liverPC (2.75 to 3.25%) and newly synthesized liver cholesterol (6.5 to 10%) were secreted into bile. The specific radioactivity of biliary PC after infusion of all-saturated FA was 3.8-6.8 times higher than that of liver PC; forC18:1 it was-only 1.7-fold. The specific radioactivity of biliary cholesterol, as compared to liver cholesterol, was 12 times higher for C-2 and fivetimes higher for MCFA. This indicates that a considerable proportion of the newly synthesized lipids was secreted into bile prior to significant mixing with preexisting liver PC and cholesterol pools. Liver PC contained 8% of unchanged C-14-C-12; while C-14-C-10 was not detected. Biliary PC, in contrast, contained 18% of unchanged C-14-C-12 and 3% C-14-C-10. These resultssuggest that after prolonged infusion of medium-chain triacylglycerols/long-chain triacylglycerols to patients, biliary PC may become enriched with MCFA, In addition, the oxidation of these FA may provide C-2 units which increase cholesterol synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:11:49