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Titolo:
Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography
Autore:
Bax, JJ; Poldermans, D; Elhendy, A; Cornel, JH; Boersma, E; Rambaldi, R; Roelandt, JRTC; Fioretti, PM;
Indirizzi:
Leiden Univ Hosp, Dept Cardiol, NL-2333 AA Leiden, Netherlands Leiden UnivHosp Leiden Netherlands NL-2333 AA 33 AA Leiden, Netherlands ThoraxCtr, Dept Cardiol, Rotterdam, Netherlands ThoraxCtr Rotterdam Netherlands r, Dept Cardiol, Rotterdam, Netherlands Med Ctr Alkmaar, Dept Cardiol, Alkmaar, Netherlands Med Ctr Alkmaar Alkmaar Netherlands Dept Cardiol, Alkmaar, Netherlands Univ Rotterdam Hosp, Dept Clin Epidemiol Stat, Rotterdam, Netherlands UnivRotterdam Hosp Rotterdam Netherlands Stat, Rotterdam, Netherlands Med Ctr Udine, Dept Cardiol, Udine, Italy Med Ctr Udine Udine ItalyMed Ctr Udine, Dept Cardiol, Udine, Italy
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 1, volume: 34, anno: 1999,
pagine: 163 - 169
SICI:
0735-1097(199907)34:1<163:IOLVEF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE DOBUTAMINE; HIBERNATING MYOCARDIUM; SURGICAL REVASCULARIZATION; CONTRAST ECHOCARDIOGRAPHY; ISCHEMIC CARDIOMYOPATHY; CONTRACTILE RESERVE; TL-201 TOMOGRAPHY; VIABILITY; DYSFUNCTION; ACCURACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bax, JJ Leiden Univ Hosp, Dept Cardiol, Rijnsburgerweg 10, NL-2333 AA Leiden, Netherlands Leiden Univ Hosp Rijnsburgerweg 10 Leiden Netherlands NL-2333 AA
Citazione:
J.J. Bax et al., "Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography", J AM COL C, 34(1), 1999, pp. 163-169

Abstract

OBJECTIVES This study was designed to address, in patients with severe ischemic left ventricular dysfunction, whether dobutamine stress echocardiography (DSE) can predict improvement of left ventricular ejection fraction (LVEF), functional status and long-term prognosis after revascularization. BACKGROUND Dobutamine stress echocardiography can predict improvement of wall motion after revascularization. The relation between viability, improvement of function, improvement of heart failure symptoms and long-term prognosis has not been studied. METHODS We studied 68 patients with DSE before revascularization; 62 patients underwent resting echocardiography/radionuclide ventriculography beforeand three months after revascularization. Long-term follow-up data (New York Heart Association [NYHA] functional class, Canadian Cardiovascular Society [CCS] classification and events) were acquired up to two years. RESULTS Patients with greater than or equal to 4 viable segments on DSE (group A, n = 22) improved in LVEF at three months (from 27 +/- 6% to 33 +/- 7%, p < 0.01), in NYHA functional class (from 3.2 +/- 0.7 to 1.6 +/- 0.5, p< 0.01) and in CCS classification (from 2.9 +/- 0.3 to 1.2 +/- 0.4, p < 0.01); in patients with <4 viable segments (group B, n = 40) LVEF and NYHA functional class did not improve, whereas CCS classification improved significantly (from 3.0 +/- 0.8 to 1.3 +/- 0.5, p < 0.01). A higher event rate wasobserved at long-term follow-up in group B versus group A (47% vs. 17%, p < 0.05). CONCLUSIONS Patients with substantial viability on DSE demonstrated improvement in LVEF and NYHA functional class after revascularization; viability was also associated with a favorable prognosis after revascularization. (C)1999 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:28:36