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Titolo:
INFLAMMATION REVEALS INHIBITION OF NOXIOUS RESPONSES OF RAT SPINAL NEURONS BY CARBAMAZEPINE
Autore:
CHAPMAN V; DICKENSON AH;
Indirizzi:
UNIV LONDON UNIV COLL,DEPT PHARMACOL,GOWER ST LONDON WC1E 6BT ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 6, volume: 8, anno: 1997,
pagine: 1399 - 1404
SICI:
0959-4965(1997)8:6<1399:IRIONR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-CHANNELS;
Keywords:
ELECTROPHYSIOLOGY; INFLAMMATION; NOCICEPTION; RAT; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
V. Chapman e A.H. Dickenson, "INFLAMMATION REVEALS INHIBITION OF NOXIOUS RESPONSES OF RAT SPINAL NEURONS BY CARBAMAZEPINE", NeuroReport, 8(6), 1997, pp. 1399-1404

Abstract

The effect of subcutaneously administered carbamazepine, a sodium channel blocker, on the electrically evoked C-fibre (noxious) vs A beta fibre (innocuous) responses of dorsal horn neurones in non-inflamed andinflamed rats (3 h after plantar injection of carrageenan) was studied. Carbamazepine (0.5-5 mg/kg) significantly reduced the noxious evoked responses of the neurones under inflammatory, but not non-inflamed, conditions. The innocuous evoked responses of the neurones were not sensitive to carbamazepine under any conditions and administration of the vehicle alone did not influence any evoked response of these neurones. We propose that there are changes in the type, or proportion of, sodium channels underlying the transmission messages following peripheral inflammation which become sensitive to carbamazepine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:41:27